effective antibiotics: Antibiotics revolutionized medicine US 1950s - - PowerPoint PPT Presentation

Modern medicine is built on access to effective antibiotics:

Antibiotics revolutionized medicine US 1950’s The introduction of penicillin increased the chance of survival of pneumonia patients from 25% to 80% Antibiotic resistance threatens a return to the pre-antibiotic era In the EU, more than 25 000 patients die from multidrug resistant bacteria annually (EMA/ECDC report) Extra health-care costs and productivity losses of at least 1,5 billion EURO per year

Antimicrobial resistance: an alarming problem

• 1. Mapping the AMR landscape funding and resources
• 2. Developing International Collaboration
• 3. Exploratory / Scoping workshops
• 4. Calls for Research Proposals
• 5. Alignment of Research Programs and AMR international

policies

• 6. Virtual Research Institute (research infrastructures,

research institutes and capacity building)

Therapeutics 29% Diagnostics 0% Surveillance 4% Transmission 49% Environment 9% Interventions 9%

RESEARCH PROJECTS

Call 1. Therapeutics Call 2. Therapeutics Call 3. Transmission Call 4. Networks/Working Groups Call 5. Interventions

Therapeutics 27% Diagnostics 14% Surveillance 27% Transmission 14% Environment 9% Interventions 9%

NETWORKS/WORKING GROUPS

JPIAMR has funded approx. 52 M€ of AMR research supporting 50 projects

• 1. JOINT RESEARCH OF PROPOSALS CALL (open)
• New Targets, New Compounds, New Tools

for New Antibiotics

• Addressing WHO priority list bacteria
• 2. NETWORKS/WORKING GROUPS CALL ON

SURVEILLANCE:

• Surveillance knowledge gaps to be

addressed by JPIAMR Networks

• 3. NETWORKS/WORKING GROUPS CALL ON VRI:
• Conceptualising a Virtual Research

Institute

@jpionamr www.jpiamr.eu

Collaboration with International Organisations

• Collaboration with International Funders

Phase I Phase II Phase III

Basic Science Pre-clinical

Market

JPIAMR EU National Science Research Agencies EC FP / ERC US BARDA EC - IMI / ND4BB US NIH / NIAID Wellcome Trust CARB-X GARDR-P EIB’s InnovFin UK / China Global Innovation Fund

Recenly Launched Existed Prior 2016

Connecting AMR researchers under the JPIAMR priority topics in a One Health approach Building capacity and strengthening capability Facilitating access to scientific information and infrastructures Global reach: Bridging geographic borders in the research community Breaking practical barriers between fields of research Increasing awareness and visibility

• f the AMR

issue Producing scientific evidence for developing policy and guidelines

15 15

VIRTUAL RESEARCH INSTITUTE

The JPIAMR Virtual Research Institute is a virtual platform to connect research networks and research performing institutes/centres to implement Antimicrobial Resistance One Health collaborative research on the JPIAMR Strategic Research Agenda priority topics by increasing knowledge, diversity, collaborations and capability.

• 1. Three joint research calls with a preliminary budget of 15M€
• New targets, new therapies, and tools addressing the WHO

pathogens priority list

• Surveillance, and we will build on our recent success and

support Research Networks across international borders.

• First VRIs networks
• 2. In response to this growing AMR challenge the JPIAMR will

launch a ground breaking AMR Virtual Research Institute.

• International Workshops, Development plan, Pilot call
• 3. JPIAMR commit to increasing activities to prioritise research

within the Strategic Research and Innovation Agenda to develop roadmaps, identify gaps and needs for research and actions.

• 4. To map AMR research funding as well as research

centres/facilities and infrastructures

• 5. To develop a database