Discovering New Drug-Drug Interactions By Text-Mining the Biomedical - - PowerPoint PPT Presentation

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Discovering New Drug-Drug Interactions By Text-Mining the Biomedical - - PowerPoint PPT Presentation

Sep 04, 2023 242 likes •321 views

Discovering New Drug-Drug Interactions By Text-Mining the Biomedical Literature Beth Percha CS 224N Final Project March 17, 2011 Background Americans are on a lot of drugs. Drug interactions are bad. We don't test for them in

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Discovering New Drug-Drug Interactions By Text-Mining the Biomedical Literature

Beth Percha CS 224N Final Project March 17, 2011

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Background

  • Americans are on a lot of drugs.
  • Drug interactions are bad.
  • We don't test for them in clinical

trials.

  • We need ways to find likely

interactions so we can watch out for them.

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Methods (I)

Start with indexed version of Medline: 17 million abstracts 88 million sentences Two lexicons: Genes (43 VIP genes) Drugs (602; at least one interaction) AND

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Methods (II)

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Results (I)

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Results (II)

Most likely interactions... Least likely interactions...