CTSA Program Webinar Wednesday, January 23, 2019 2:00 3:00 ET - - PowerPoint PPT Presentation

CTSA Program Webinar

Wednesday, January 23, 2019 2:00 – 3:00 ET

Agenda

Time Topic Presenter

2:00 - 2:15 Welcome NCATS and CTSA Program Updates Christopher P. Austin Clare Schmitt 2:15 – 2:20 Common Metrics Update Deborah Ossip (CLIC) 2:20 - 2:25 CD2H IDEA Competition Justin Guinney (CD2H) 2:25 - 2:55 IDeA Presentation Ming Lei Rafael Gorospe 2:55 - 3:00 Adjourn

2

NCATS and CTSA Program Updates

Christopher P. Austin & Clare Schmitt

4

Year in Review

Fiscal Year 2018

FY 2018: NIH IC Budgets

NIH IC FY2018 Final NCI $5,965 NIAID $5,260 NHLBI $3,383 NIGMS $2,785 NIA $2,574 NINDS $2,188 NIDDK $2,121 OD $1,926 NIMH $1,755 NICHD $1,452 NIDA $1,384 NIEHS $828 NEI $772 NCATS $742 NIAMS $587 NHGRI $557 NIAAA $510 NIDCD $460 NIDCR $448 NLM $429 NIBIB $378 NIMHD $303 NINR $158 NCCIH $142 FIC $76

Note: Does not reflect $20.1M in HEAL Transfer from NINDS to NCATS

FY 2018: NCATS Distribution

DCI

(CTSA)

DPI CAN SBIR Rare Diseases HEAL NTU Other

Total $760.7M

(Includes $20.1M for HEAL)

$0 $100 $200 $300 $400 $500 $600 $700 $800 $900 2012 2013 2014 2015 2016 2017 2018 Actuals (Dollars in Millions) Fiscal Year

FY 2012-2018: Trends in NCATS Budget

Heal Funds

Division of Clinical Innovation

9

CTSA Program Spending by Fiscal Year

NCATS Clinical and Translational Science Awards Program Fiscal Year 2014 Actual Fiscal Year 2015 Actual Fiscal Year 2016 Actual Fiscal Year 2017 Actual Fiscal Year 2018 Estimate CTSA Program Hubs Number of Hub awards 58 58 57 57 58 Hub Awards (A UL1 award with a linked KL2 award and an optional TL1 award) $404,954,499 $441,922,552 $449,584,228 $447,800,122 $459,342,839 Administrative Supplements to Hub Awards $44,204,713 $18,534,775 $9,851,866 $6,367,377 $21,790,276 Bridge Awards (U54) $16,798,746 $3,528,613 $3,560,718 $3,497,558 $0 CTSA Program Collaboration Initiatives (per IOM Recommendations) - all awards to CTSA institutions CTSA Program Collaborative Innovation Awards (U01/R21) $8,602,736 $14,402,042 $24,130,055 Consortium Centers (U24/U54) RIC/TIC/CD2H/Coordination $2,420,706 $2,741,255 $16,354,755 $29,878,310 $22,037,558 Subtotal of Funding to CTSA Program Institutions $468,378,664 $466,727,195 $487,954,303 $501,945,409 $527,300,728 Other CTSA Program Activities6 Other (K23/R13/U13/U19/T15/U2C/U24) $1,402,448 $1,277,800 $265,000 $600,000 $643,697 Loan Repayment Program $2,006,148 $1,986,781 $2,001,190 $2,009,444 $2,508,139 Program Management (Includes NIH and DHHS assessments and transfers) $5,432,517 $7,399,063 $9,779,507 $11,569,957 $12,326,808 Grand Total $477,219,777 $477,390,839 $500,000,000 $516,124,810 $542,779,372

https://ncats.nih.gov/files/ctsa-funding-information.pdf

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FY18 CTSA Program Hub Awards

Albert Einstein College of Medicine Case Western Reserve University Duke University Harvard Medical School Indiana University - Purdue University at Indianapolis Ohio State University Scripps Research Institute Tufts University Boston University of Colorado Denver University of Iowa University Of Miami School of Medicine University of Minnesota University of North Carolina Chapel Hill University of Texas Health Science Center University of Utah Virginia Commonwealth University

16 Awards $ 134,887,166 expended

FY18 CTSA Program Administrative Supplements Enhancing Network Capacity (PA-16-328)

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7 Awards $3,379,290 expended Dissemination of local innovations

• Informatics
• Training and education
• Methods and processes
• Community engagement strategies
• Entrepreneurship
• Team science
• Clinical trial management and

recruitment

• Regulatory guidance
• Precision Medicine

FY18 CTSA Program Administrative Supplements Priority Research Areas (NOT-TR-18-022)

• Total: ~ $14 M
• 27 Awards
• 24 CTSA Program Hub

Institutions

• 15 Additional hubs

participating

• 2 CTSA Program

Collaborative Innovation Awards

Community/ Collaboration Engagement 4% Education and/or Training 11% Informatics 5% Instrumentation 1% Methods and Processes 13% Opioid Crisis 16% Rare Diseases Research 2% Research Software Applications 48%

Supplements awarded to CTSA Program UL1s and Collaborative Innovation Awards by priority research area as a percentage of total awarded supplements

Looking ahead to remainder of FY 2019 …

FY 2019

Ø P.L. 115-245 - Department of Defense and Labor, Health and Human Services, and Education Appropriations Act, 2019 and Continuing Appropriations Act, 2019

• Became law on 9/28/2018
• NIH: $39.084 billion ($2 billion increase, or 5.4%, above FY 2018)

FY 2018 & 2019: NIH IC Budgets

(Dollars in Millions)

**Does not include $20.1M in HEAL Transfer from NINDS in 2018

NIH IC FY2018 Final FY2019 Enacted NCI $5,965 $6,144 NIAID $5,260 $5,383 NHLBI $3,383 $3,488 NIA $2,574 $3,083 NIGMS $2,785 $2,873 NINDS $2,188 $2,274 NIDDK $2,121 $2,030 OD $1,926 $1,917 NIMH $1,755 $1,870 NICHD $1,452 $1,506 NIDA $1,384 $1,420 NCATS** $742 $806 NEI $772 $797 NIEHS $828 $775 NIAMS $587 $605 NHGRI $557 $576 NIAAA $510 $526 NIDCD $460 $474 NIDCR $448 $462 NLM $429 $442 NIBIB $378 $389 NIMHD $303 $315 NINR $158 $163 NCCIH $142 $146 FIC $76 $78

Barry Coller, M.D. Rockefeller University

CTSA Program Steering Committee Co-Chair 2019 - 2020

John Buse, M.D., Ph.D. University of North Carolina, Chapel Hill UL1 Member Rachel Hess, M.D., M.S. University of Utah UL1 Member Julianne Imperato - McGinley, M.D. Weill Cornell UL1 Member Patricia Winokur, M.D. University of Iowa UL1 Member Gerald Stacy University of Chicago Administrator Member

Welcome New CTSA Program Steering Committee Members!

2019 – 2021 Cohort

NIH Helping to End Addiction Long-Term (HEAL)SM Initiative

• Application receipt date

extended to February 11, 2019

• Pain Management Effectiveness Research

Network Funding Opportunity (NS-19-021): https://grants.nih.gov/grants/guide/rfa- files/RFA-NS-19-021.html

• TIN Resources:

https://trialinnovationnetwork.org/heal-pain- ern-other-heal-foas/

• Questions? Please contact Jane Atkinson

(jatkinso@mail.nih.gov) or Cynthia Boucher (cynthia.boucher@nih.gov)

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NIH HEALSM Initiative - NCATS Opportunities

3-D Bioprinted Tissue Models of Pain, Opioid Use Disorder and Overdose (RFA-TR-19-005)

• Letters of Intent Due: Jan. 28, 2019; Applications Due: Feb. 28, 2019
• NCATS is supporting collaborations with the external research community to develop and use 3-D

biofabricated tissue models as new drug screening platforms to advance pre-clinical discovery and development of non-addictive treatments for pain, opioid use disorder and overdose. NCATS intends to fund approximately two to three awards for a total of $1.5 million in fiscal year 2019. Tissue Chips to Model Pain, Addiction and Overdose (RFA-TR-19-003)

• Letters of Intent Due: Jan. 28, 2019; Applications Due: Feb. 28, 2019
• Selected applicants will receive funding to create and test devices that can model the mechanisms
• r effects of pain-relevant signaling, addiction or opioid use disorders using human tissues in tissue-

and organ-on-chip systems. NCATS intends to commit approximately $5 million in fiscal year 2019 to fund four to six awards. ASPIRE Design Challenges (NOT-TR-18-031)

• Challenges Open: Dec. 31, 2018; Submission Deadline: May 31, 2019
• Winners Announced: August 2019
• NCATS has issued a series of challenge competitions for novel chemical compound concepts that

have the potential to address pain, addiction and overdose. NCATS will issue up to 22 prizes for the creation of a database, an electronic laboratory knowledge portal, machine learning algorithms and biological assays. An additional challenge will focus on a combined solution for two or more areas. View and the ASPIRE Design Challenges page to learn more.

FOA Updates

• CCIA FOA renewed for FY19
• Enhancing Network Capacity (2 receipt dates FY19)
• Competitive Supplements for FY20 awards
• Future FOA
• Obtain feedback on process (RFA issues) and program objectives
• Internal: NCATS
• External
• RFI & Town Hall
• Study Section Reviewers
• CTSA Program Steering Committee: solicit and present feedback

from pods

December 2018

Collaborative Innovation Award (U01)

3 or more CTSA Program hubs External Peer Review Collaborative Innovation

Collaborative Innovation Award (R21)

2 or more CTSA Program hubs External Peer Review Collaborative Innovation – High Risk/ High Reward

Enhancing Network Capacity (Administrative Supplements)

2 or more CTSA Program hubs Internal Administrative Review Dissemination

FY19 NCATS CTSA Program Collaborative Suite of Awards

Eligibility Review Type Purpose https://ncats.nih.gov/ctsa/projects/ccia Foster research collaboration to develop, demonstrate and disseminate innovative, experimental approaches to overcoming translational science roadblocks. Enhance network capacity through implementing, assessing, and/or disseminating discoveries in methods, approaches, education, and training in clinical and translational science within the scope of the parent grant.

Collaborative Innovation Awards: Re-Issued FOAs

For both the R21 and U01 FOAs: Receipt dates are harmonized: q U01 (PAR-19-099) & R21 (PAR-19-100) - next receipt date March 8, 2019 Eligibility Criteria is Enhanced: q An application must involve investigators who are supported by CTSA Program hub institutions from at least three (for U01) / two (for R21) different and currently funded CTSA Program hubs as of the due date of the application. Hubs in a no-cost extension do not meet the eligibility criteria. q The PD/PI or contact PD/PI must be employed by and/or a recipient of funding from a currently funded CTSA Program hub institution as defined above in Eligible

• Organizations. ‘CTSA Program Hub Institution’ includes the recipients of the CTSA Program

Hub award, as well as any institutions listed as partners in the CTSA Program Hub UL1 awards.

Collaborative Innovation Awards: Re-Issued FOAs

For the U01 FOA

Award Project Period and Award Budget is modified for the U01

q The maximum project period is 4 years. q For clinical projects, no more than $750,000 direct costs annual budget should be requested. q For non-clinical projects, no more than $400,000 direct costs annual budget should be requested.

For More Information and a List of Funded Awards

q Collaborative Innovation through the CTSA Program: https://ncats.nih.gov/ctsa/projects/ccia q FAQs: https://ncats.nih.gov/ctsa/funding/innovation-faq q Contact: CTSA_COLLABORATIVEINNOVATION@mail.nih.gov

Administrative Update: Human Subjects Research Prior Approval Requests

• REMINDER: Effective Jan. 1, 2019, Prior Approval

requests that involve human subjects research, including studies that may be considered exempt, must be submitted via the new NIH eRA Human Subjects System (HSS)

• NCATS is trying to fit our processes into this new

system

• Revised Addendum and Instructions

2019 Spring CTSA Program Meeting

• Focus: TS workforce education/training and DTF Groups
• Steering Committee Meeting
• TL1 PI Meeting
• KL2 PI Meeting
• Workforce DTF
• Collaboration & Engagement DTF
• Methods & Processes DTF
• 2019 Meeting: Adjacent to ACTS Meeting; Martin Zand and

ACTS President Bob Kimberly collaborated on scheduling

• CLIC Registration is open!

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Common Metrics Initiative Update

CTSA Program Webinar January 23, 2019

Multi-Year CM Report

Target release date: February 28 Send to: PIs, Administrator, Evaluator How you will receive the report:

• Report will be accessed via the CLIC website.
• Detail communication is forthcoming.

2019 SPRING CTSA PROGRAM GROUP MEETINGS

March 4 – 5, 2019, Washington, D.C.

Scheduled Meetings:

• CTSA Program Steering

Committee

• Hub Communicators
• Common Metrics Initiative
• Collaboration & Engagement DTF
• Methods & Processes DTF
• Workforce Development DTF
• KL2 PI/Directors
• TL1 PI/Directors

REGISTRATION NOW LIVE

Register by Feb. 11. Visit the CLIC Events Page to learn more & register.

Common Metrics Session

Date: Tuesday, March 5, 2019 Time: 8:30-12noon Audience: PIs, Administrators, & Evaluators Registration is now live

2018 CM Data Update

Workgroup Name

Workgroup Name

CD2H SHow and Tell, Date

CD2H Idea Challenge

CTSA PI Meeting, January 23, 2019 Justin Guinney

Why Community Challenges?

We are excited about data challenges :

• Create new science and methodology
• Excite problem-solving drive in individuals and stimulate

collaborations

• Identify innovative approaches and compare methods
• Engage research communities: curators, informaticists,

computer scientists, etc.

DREAM is a platform for enabling community challenges

DREAM Challenges are run with the non-profit Sage Bionetworks on their collaboration platform, Synapse. Open science community challenges focused on biomedical and biological questions. Brings together data providers, researchers, and curators to solve biomedical problems

Example DREAM Challenge

Challenge goal: reduce high false positive rate in mammography screening Challenge Achievements:

• Successful demonstration of inter-institutional data sharing using 1.1+

million mammogram images

• Dozens of expert AI teams participated from around the world, establishing

benchmarks in the field

• Demonstrated combining AI with radiologist call can increase specificity at

fixed sensitivity (0.86)

Radiologist: 0.90 specificity Radiologist + AI: 0.92 specificity

Call for Proposals: The CD2H $100K Idea Competition

• Opportunity to turn your scientific question into a

DREAM Challenge to be tackled by teams around the world.

• Receive up to a $100K subcontract to run the

DREAM Challenge in collaboration with the CD2H.

• Eligibility: any researcher, clinician, or staff member

affiliated with an institution that has a CTSA hub (with the exception of sites that already receive subcontracts from CD2H).

Call for Proposals: The CD2H $100K Idea Competition

Selection criteria:

• Scientific question(s) is of broad interest to CTSAs
• Question(s) is tractable, and data necessary to solve

question is accessible to participants

• Solution to question(s) can be quantitatively

measured. Deadline for initial Idea Competition proposals: February 15, 2019 To learn more and submit a proposal please visit: http://bit.ly/CD2H_idea

CD2H DREAM Challenges

Other challenges in preparation:

• EHR Predictive Analytics Challenge(s):

application of federated algorithms across EHR systems for patient level prediction

• NLP Challenge: comparison & assessment of NLP

approaches

• NCI / NCATS Meta-data Automation Challenge:

improving methods for data curation

To learn more or contribute: please contact justin.guinney@sagebionetworks.org

IDeA and IDeA CTRs

Ming Lei, Ph.D. Director, Division for Research Capacity Building, NIGMS/NIH

https://publications.nigms.nih.gov/strategicplan/NIGMS-strategic-plan.pdf

• Establishment: authorized by

Congress in 1993 (NIH Revitalization Act)

• Goal: Enhance geographical

distribution of NIH research funds and strengthen research capacity

• IDeA Eligibility: 23 states and

Puerto Rico

• FY2019 Budget: $361 M

Institutional Development Award (IDeA) Program

IDeA Funding Initiatives/Programs

• IDeA Program Infrastructure for Clinical and Translational

Research (IDeA-CTR)

• Centers of Biomedical Research Excellence (COBRE)
• IDeA Networks of Biomedical Research Excellence (INBRE)
• IDeA Co-Funding
• IDeA Regional Technology Transfer Accelerator Hubs

(STTR Hubs)

• IDeA State Pediatric Clinical Trial Network(ISPCTN)

COBREs: Supporting Faculty Development through Competitive Research

Objective: To develop advanced research infrastructure and a critical mass of investigators around thematic research areas in IDeA state institutions Key components: Research Core Facilities (1-3) Research Projects led by junior investigators (3-5) Coordination and Mentoring led by senior PIs (Administrative Core) Duration/Budget: Phase I (P20, Development): 5 years, $1.5 M/yr DC Phase II (P20, Enhancement): 5 years, $1.5 M/yr DC Phase III (P30, Transition): 5 years, $750K/yr DC Number of active awards: ~130

INBREs (24 active awards)

Objective: To build a statewide multi-disciplinary research network including the state’s research-intensive institutions and primarily undergraduate institutions (PUIs), develop a pipeline of health science researchers, and enhance health literacy of the state’s workforce Key components:

• Network Coordination (PI and PC) and Mentoring (at research-intensive institutions)
• Research Core Facilities (at research-intensive institutions)
• Developmental Research Project Program (primarily at PUIs)
• Curriculum Development (at PUIs)

Duration/Budget:

• 5-year, $2.5M/yr DC
• No less than $1.5 M spent at PUIs
• Renewable

Number of active awards: 24

INBRE: State-wide Networks to Develop Future Researchers and Workforce

IDeA Co-Funding

Objective: To support R01, R15 and S10 grant applications from IDeA states to all NIH Institutes/Centers (ICs) that received excellent ratings but fell short of the ICs’ pay lines. Duration/Budget: IDeA program funds

• each of the first two years of an R01
• the first year of an R15
• the ehtile request of a S10

Selection Criteria:

• Nominated by ICs
• Priority to ESIs
• NIH IC representation
• IDeA state distribution
• Research projects address the home state’s prevalent health issues
• Research projects aligned with NIH priorities

Number of R01s and R15s the IDeA program Co-funds each year: ~40

https://www.nigms.nih.gov/News/results/Pages/20180905.aspx Objective: To support regional technology transfer accelerator hubs that help develop infrastructure and an entrepreneurial culture at the IDeA institutions Key features: Small business concerns (SBCs) partner with academic institutions to develop and implement programs/tools that promoting entrepreneurship and technology transfer; institutional commitments are expected of academic partners Duration/Budget: Up to three years, $3.5M Mechanism: UT2 STTR Cooperative Agreement – (Fast-Track)

Regional Tech Transfer Accelerator Hubs for IDeA States (currently 4 active STTR Hubs-one in each IDeA region)

IDeA State Pediatric Clinical Trial Network (ISPCTN)

Funded by the Environmental Influences on Child Health Outcomes (ECHO) Program

• To provide access to state-of-the-art clinical trials to medically

underserved and rural populations in the five ECHO priority areas of upper and lower airway disease; obesity; pre-, peri-, and postnatal

• utcomes; neurodevelopment; and overall positive health.
• To build national pediatric research capacity to conduct clinical trials

by providing professional development for faculty, team support and infrastructure building.

• To leverage the existing IDeA infrastructure by embedding clinical

trials experts at IDeA state locations and facilitating their partnership with other academic institutions.

ISPCTN Awards

• Alaska Native Tribal Health Consortium, Anchorage, Alaska
• Arkansas Children’s Research Institute, Little Rock, Arkansas
• Dartmouth College, Hanover, New Hampshire
• Louisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana
• Nemours Alfred I. duPont Hospital for Children, Wilmington, Delaware
• Rhode Island Hospital, Providence, Rhode Island
• University of Hawaii at Manoa, Honolulu, Hawaii
• University of Kansas Medical Center, Kansas City, Kansas
• University of Louisville, Louisville, Kentucky
• University of Mississippi Medical Center, Jackson, Mississippi
• University of Montana, Missoula, Montana
• University of Nebraska Medical Center, Omaha, Nebraska
• University of New Mexico Health Sciences Center, Albuquerque, New Mexico
• University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
• University of South Carolina at Columbia, Columbia, South Carolina
• University of Vermont and State Agricultural College, Burlington, Vermont
• West Virginia University, Morgantown, West Virginia

Data Coordinating and Operations Center (DCOC) at University of Arkansas for Medical Sciences (UAMS)

48

IDeA States Pediatric Clinical Trials Network (ISPCTN)

HI LA NY TX DE MT NM SD OK TN AK CA WA OR CO AZ WI MN MS AL FL GA SC NC VA IL NV WY ND NE KS AR KY WV ME NH VT UT IA MO MI MA IN OH PA NJ CT MD RI PR ID

Clinical Trial Site DCOC IDeA-CTR

IDeA Infrastructure for Clinical and Translational Research

(U54 Cooperative Agreement; First award: 2012) Objective:

• Support the development of infrastructure and human resources required to

conduct clinical and translational research in IDeA-eligible states.

• Enhance the ability of IDeA institutions and investigators to develop competitive

clinical and translational research programs.

• Foster and sustain collaboration and coordination of clinical and translational

activities within and across IDeA institutions or organizations.

• Address health conditions that affect the medically underserved and/or that are

prevalent among populations in IDeA states. Duration/Budget:

• 5-year award, $4M/yr TC
• renewable

Active awards: 11, in IDeA states with academic medical centers but no

• CTSAs. CTRs often multiple institutions

Structure of IDeA-CTR Awards

(U54 Cooperative Agreement)

Professional Development Core Community Engagement Core Biostatistics, Epidemiology, and Research Design Core (BERD) Pilot Projects Program Tracking and Evaluation Faculty Recruitment Clinical Research Resources and Facilities

Cyberinfrastructure Enhancement Core

Ethics and Regulatory Knowledge Biomedical Informatics and Support Services Research Technologies and Resources

ADMINISTRATIVE CORE

CUR Dialogue 2015

LA NY TX DE MT NM SD OK TN CA WA OR CO AZ WI MN MS AL FL GA SC NC VA IL NV WY ID ND NE KS AR KY WV ME NH VT UT IA MO MI MA IN OH PA NJ CT MD RI HI AK PR

Legend Lead Institution Network Collaborations Other IDeA State

• IDeA-CTRs (11) are in States with no CTSAs
• Six CTSAs are in IDeA States (AR, KS, KY, NH, NM, SC)

52

LA NY TX DE MT NM SD OK TN CA WA OR CO AZ WI MN MS AL FL GA SC NC VA IL NV WY ID ND NE KS AR KY WV ME NH VT UT IA MO MI MA IN OH PA NJ CT MD RI HI AK PR

IDeA-CTR

Geographical Distribution (Total Awards = 11)

CTR Lead Institution Partnering Institution CTSA (IDeA State) CTSA (Non-IDeA State) RCMI-CTR

IDeA CTRs Focus on Diseases Prevalent in Their Respective States

State/PI Program Scientific Focus

ND/BASSON, MARC D Dakota Cancer Collaborative on Translational Activity CANCER/Rural Health/Tribal Health DE/BINDER-MACLEOD, STUART A Delaware Clinical and Translational Research ACCEL Program Delaware Health Issues WV/HODDER, SALLY LYNN West Virginia Clinical and Translational Science Institute Appalachian Health Disparities OK/JAMES, JUDITH A Oklahoma Shared Clinical and Translational Resources Oklahoma Health Concerns/Tribal Health LA/KIRWAN, JOHN P Louisiana Clinical and Translational Science Center LA Chronic Diseases (obesity, diabetes, cardiovascular disease, cancer, aging and cognitive dysfunction) NV/KUMAR, PARVESH Clinical and Translational Research Infrastructure Network IDeA-CTR Health Disparities in the Mountain West Region RI/PADBURY, JAMES F RI-Center for Clinical and Translational Science Rhode Island Health Concerns NE/RIZZO, MATTHEW Great Plains IDeA-CTR Aging and Rural Health in the Great Plain States ME/ROSEN, CLIFFORD JAMES Northern New England Clinical and Translational Research Network Rural and Community Health in Northern New England (cancer, cardiovascular disease, and substance abuse) MT-AK/VOYICH, JOVANKA M American Indian - Alaska Native Clinical and Translational Research Center (AI-AN CTRC) American Indian - Alaska Native Health Concerns MS/WILSON, JAMES GRAHAM Mississippi Center for Clinical and Translational Research Mississippi Health Disparities related to Obesity

CTRs: Partners of CTSAs and ISPCTN

State/PI Program CTSA partnership ISPCTN site in the State(s)

ND/BASSON, MARC D Dakota Cancer Collaborative on Translational Activity DE/BINDER-MACLEOD, STUART A Delaware Clinical and Translational Research ACCEL Program MUSC Y WV/HODDER, SALLY LYNN West Virginia Clinical and Translational Science Institute UK, U Pittsburgh Y OK/JAMES, JUDITH A Oklahoma Shared Clinical and Translational Resources Y LA/KIRWAN, JOHN P Louisiana Clinical and Translational Science Center Y NV/KUMAR, PARVESH Clinical and Translational Research Infrastructure Network IDeA-CTR U NM Y (NM, HI, AK, MT) RI/PADBURY, JAMES F RI-Center for Clinical and Translational Science Y NE/RIZZO, MATTHEW Great Plains IDeA-CTR KUMC Y (NE, KS) ME/ROSEN, CLIFFORD JAMES Northern New England Clinical and Translational Research Network Dartmouth Y (VT, NH) MT-AK/VOYICH, JOVANKA M American Indian - Alaska Native Clinical and Translational Research Center (AI-AN CTRC) U Wash Y (AK, MT) MS/WILSON, JAMES GRAHAM Mississippi Center for Clinical and Translational Research Mayo Clinic Y

CTRs Don’t Have a KL2-like Training Component:

i-MRSP: an NIGMS-NIH Clinical Center Joint Program

• Medical Research Scholars Program (MRSP)
• A resident immersion program at the NIH Clinical Center offers ~ 40 medical

students across the country a year-long research experience under mentorship of NIH intramural investigators

• Participation of the program by students from IDeA states has been limited
• IDeA State Students @ MSRP (i-MRSP) started January, 2009
• IDeA-CTRs recruit medical students from their respective states to apply
• The Clinical Center identifies qualified candidates through a standard

review/interview process, and makes selections supported by MRSP funds

• In addition to selections made by MRSP, NIGMS will support up to 5

students from IDeA states to join MRSP each year

Questions & Comments