Cowen and Company Health Care Conference Pfizer Oncology Andy - - PowerPoint PPT Presentation
Cowen and Company Health Care Conference Pfizer Oncology Andy - - PowerPoint PPT Presentation
Cowen and Company Health Care Conference Pfizer Oncology Andy Schmeltz Global President, Pfizer Oncology March 14, 2018 Forward Looking Statements This presentation includes forward-looking statements about, among other things, Pfizers
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Forward Looking Statements
This presentation includes forward-looking statements about, among other things, Pfizer’s oncology in-line products and product candidates, including anticipated regulatory submissions, approvals, performance and potential benefits of Pfizer's
- ncology products and product candidates, that are subject to substantial risks
and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Additional information regarding these factors can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2017 and in our subsequent reports on Form 10-Q, including in the sections thereof captioned “Risk Factors” and “Forward-Looking Information and Factors that May Affect Future Results”, as well as in our subsequent reports on Form 8-K, all of which are filed with the U.S. Securities and Exchange Commission (SEC) and available at www.sec.gov and www.pfizer.com. The forward-looking statements in this presentation speak only as of the original date of this presentation, and we undertake no obligation to update or revise any
- f these statements.
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Pfizer Oncology Growth Trajectory
Growing in-line portfolio fueled by IBRANCE & XTANDI with potential for multiple launches on the horizon
Curve is for illustrative purposes only *numbers for 2018-2020 reflect potential approvals and indications that are expected and may not materialize
Opportunistic & Niche Growth & Leadership
Mindset
GLASDEGIB TALAZOPARIB DACOMITINIB LORLATINIB # Approved Medicines*
2 3 5 5 5 6 7 10 12 14 14
# Approved Indications*
3 5 7 8 8 9 11 17 20 21 28
E* E* E* 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 Revenue $B
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A Rich Oncology Pipeline
1 Registration/Approvals: Only includes major regions (US, EU, JPN, CHN).
* Additional clinical studies being conducted in other tumor types/segments and earlier phases. utomilumab
(PF-05082566)(B164)
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Phase 1
p-cadherin LP DART
(PF-06671008)(B783) Angiogenesis Cell Signal Transduction / Oncogenic Driver Immunotherapy Cell Cycle & Metabolism Antibody Drug Conjugate Therapeutic Vaccine
VBIR1
(PF-06753512)(B779)
Anti-PD1
(PF-06801591)(B801)
GD3
(PF-06688992)(B802)
NG-HER2
(PF-06804103)(C054)
BCMA CD3
(PF-06863135)(C107)
UCART19
(PF-06883541)(C119)
gedatolisib
(PF-05212384)(B215)
OX-40
(PF-04518600)(B060)
PTK7
(PF-06647020)(B766)
EGFR T790M
(PF-06747775)(B797)
Anti-MCSF
(PD-360324)(A626)
axitinib*
RCC Adj
6
Phase 3
palbociclib*
BC
avelumab*
NSCLC, Ovarian, RCC, Gastric, urothelial,SCCHN
talazoparib*
gBRCA mut mBC, CRPC
enzalutamide*
CRPC, HSPC
lorlatinib
ALK+ NSCLC 1L
sunitinib
RCC Adj (EU)
dacomitinib*
NSCLC (US,EU)
lorlatinib
ALK+ NSCLC 2L+ (US,EU,JPN)
Registration1
bosutinib*
CML 1L (EU)
gemtuzumab
- zogamicin
AML (EU)
enzalutamide*
CRPC (US,EU)
6
Phase 2
4
glasdegib*
AML (Fit & Unfit)
avelumab*
NSCLC, SCLC, H&N, Melanoma, TNBC, MCC
talazoparib*
CRPC
sunitinib
Pediatric GIST
crizotinib*
ALCL / Neuroblastoma (pediatric CRCs)
as of February, 2018
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- Partner with key
stakeholders in the breast and prostate cancer communities
- Generate evidence
for broader and
- ptimal use
- Talazoparib: PARP
inhibitior
- Avelumab: backbone
PD-L1 therapy
- Identify and
interrogate rational combinations with IO and non-IO mechanisms
- Innovative and
meaningful patient engagement
- Advancing access
via outcomes and real world evidence
- Redefining life with
cancer
Key Focus Areas
IBRANCE & XTANDI* Pipeline
Focused to Realize Our Vision
To Be a Leader in Oncology by Speeding Cures and Accessible Breakthrough Medicines to Patients, Redefining Life with Cancer
*Pfizer and Astellas jointly commercialize XTANDI in the United States