Cowen and Company Health Care Conference Pfizer Oncology Andy - - PowerPoint PPT Presentation

cowen and company health care conference pfizer oncology
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Cowen and Company Health Care Conference Pfizer Oncology Andy - - PowerPoint PPT Presentation

Cowen and Company Health Care Conference Pfizer Oncology Andy Schmeltz Global President, Pfizer Oncology March 14, 2018 Forward Looking Statements This presentation includes forward-looking statements about, among other things, Pfizers


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Cowen and Company Health Care Conference Pfizer Oncology

Andy Schmeltz Global President, Pfizer Oncology March 14, 2018

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Forward Looking Statements

This presentation includes forward-looking statements about, among other things, Pfizer’s oncology in-line products and product candidates, including anticipated regulatory submissions, approvals, performance and potential benefits of Pfizer's

  • ncology products and product candidates, that are subject to substantial risks

and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Additional information regarding these factors can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2017 and in our subsequent reports on Form 10-Q, including in the sections thereof captioned “Risk Factors” and “Forward-Looking Information and Factors that May Affect Future Results”, as well as in our subsequent reports on Form 8-K, all of which are filed with the U.S. Securities and Exchange Commission (SEC) and available at www.sec.gov and www.pfizer.com. The forward-looking statements in this presentation speak only as of the original date of this presentation, and we undertake no obligation to update or revise any

  • f these statements.
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Pfizer Oncology Growth Trajectory

Growing in-line portfolio fueled by IBRANCE & XTANDI with potential for multiple launches on the horizon

Curve is for illustrative purposes only *numbers for 2018-2020 reflect potential approvals and indications that are expected and may not materialize

Opportunistic & Niche Growth & Leadership

Mindset

GLASDEGIB TALAZOPARIB DACOMITINIB LORLATINIB # Approved Medicines*

2 3 5 5 5 6 7 10 12 14 14

# Approved Indications*

3 5 7 8 8 9 11 17 20 21 28

E* E* E* 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 Revenue $B

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A Rich Oncology Pipeline

1 Registration/Approvals: Only includes major regions (US, EU, JPN, CHN).

* Additional clinical studies being conducted in other tumor types/segments and earlier phases. utomilumab

(PF-05082566)(B164)

13

Phase 1

p-cadherin LP DART

(PF-06671008)(B783) Angiogenesis Cell Signal Transduction / Oncogenic Driver Immunotherapy Cell Cycle & Metabolism Antibody Drug Conjugate Therapeutic Vaccine

VBIR1

(PF-06753512)(B779)

Anti-PD1

(PF-06801591)(B801)

GD3

(PF-06688992)(B802)

NG-HER2

(PF-06804103)(C054)

BCMA CD3

(PF-06863135)(C107)

UCART19

(PF-06883541)(C119)

gedatolisib

(PF-05212384)(B215)

OX-40

(PF-04518600)(B060)

PTK7

(PF-06647020)(B766)

EGFR T790M

(PF-06747775)(B797)

Anti-MCSF

(PD-360324)(A626)

axitinib*

RCC Adj

6

Phase 3

palbociclib*

BC

avelumab*

NSCLC, Ovarian, RCC, Gastric, urothelial,SCCHN

talazoparib*

gBRCA mut mBC, CRPC

enzalutamide*

CRPC, HSPC

lorlatinib

ALK+ NSCLC 1L

sunitinib

RCC Adj (EU)

dacomitinib*

NSCLC (US,EU)

lorlatinib

ALK+ NSCLC 2L+ (US,EU,JPN)

Registration1

bosutinib*

CML 1L (EU)

gemtuzumab

  • zogamicin

AML (EU)

enzalutamide*

CRPC (US,EU)

6

Phase 2

4

glasdegib*

AML (Fit & Unfit)

avelumab*

NSCLC, SCLC, H&N, Melanoma, TNBC, MCC

talazoparib*

CRPC

sunitinib

Pediatric GIST

crizotinib*

ALCL / Neuroblastoma (pediatric CRCs)

as of February, 2018

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  • Partner with key

stakeholders in the breast and prostate cancer communities

  • Generate evidence

for broader and

  • ptimal use
  • Talazoparib: PARP

inhibitior

  • Avelumab: backbone

PD-L1 therapy

  • Identify and

interrogate rational combinations with IO and non-IO mechanisms

  • Innovative and

meaningful patient engagement

  • Advancing access

via outcomes and real world evidence

  • Redefining life with

cancer

Key Focus Areas

IBRANCE & XTANDI* Pipeline

Focused to Realize Our Vision

To Be a Leader in Oncology by Speeding Cures and Accessible Breakthrough Medicines to Patients, Redefining Life with Cancer

*Pfizer and Astellas jointly commercialize XTANDI in the United States

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Q&A

Andy Schmeltz Global President, Pfizer Oncology