CardioInspect Diagnostic and Monitoring Systems for Congestive - PowerPoint PPT Presentation

CardioInspect Diagnostic and Monitoring Systems for Congestive Heart Failure (CHF) Patients TAU Future Technology Development L.P.

The Technology  EIT – Electrical Impedance Tomography • Electrical Impedance tissue property is imaged non invasively Current Source  Chest belt with Unit disposable electrodes Control and Acquisition Unit Voltage Measurement Unit Reconstruction Algorithm

CardioInspect Standalone Prototype Clinical Trials

Clinical Results Monitoring Lung Edema Level Edema Improvement +16% Lung Resistivity [Ohm*cm] +35% Measurement # Significant increase in resistivity values reflect improvement of lung fluid level

The Telemedicine Home System Recording Phase Transmitting Phase Clinical data as received at the medical center

The Telemedicine Home System Healthy Subject CHF Patient

Confidential Diagnostic and Monitoring EIT System for Osteoporosis

Confidential Vision Statement Revolutionize the diagnostics and monitoring of Osteoporosis in the clinic and at home by introducing an EIT based technology that can be integrated within a hand wristband 8

Confidential Proposed Solution Deliver a novel Electrical Impedance Tomography (EIT) based technology as an alternative to the DEXA solution:  Inexpensive relative to other existing techniques  Does not utilize ionizing radiation and well suited for long-term tracking that is often required in Osteoporosis management  Utilized using simple and compact hardware; Can be applied in small clinics and at home Utilizing EIT: Current Source Unit  Provides information about the spatial electrical conductivity distribution within the human body Control and Acquisition  Based on applying small magnitude alternating Unit electric currents to the body and measuring Voltage developing electric potentials on the body surface Measurement Unit  The large variation in bone tissue electric and dielectric properties during Osteoporosis, makes EIT a Reconstruction promising technique for monitoring and diagnosing Algorithm 9

Confidential Technical Background (1 of 4) Mathematical Formulation Inverse formulation - Calculation of Forward formulation - Calculation the spatial conductivity distribution of the spatial electrical potential due to known current sources and due to known current sources and surface voltages conductivity distribution         f ( , J ) f ( J , ) source source surface Solution by Maxwell' s EM fields Solution by iterative equations in a volume conductor :            Newton - Raphson algorithm J source 10

Confidential Technical Background (2 of 4) The Newton-Raphson algorithm Initial Guess -  0 Forward Solver Calculated surface potentials Measured surface Cost potentials function yes no <   k+1 =  k +  k+1 End 11

Confidential Technical Background (3 of 4) Numerical computational simulation Displayed above are human body computerized model cross section results of the wrist and forearm as received from our preliminary numerical study, using a set of 5 electrodes on the surface of the wrist and measuring the surface potentials. Very strong correlation was found between the Impedance and BMD 12

Confidential Technical Background (4 of 4) Preliminary real measurements using the developed prototype The prototype during measurement Results of 7 real tests from 5 healthy subjects and 2 patients with documented osteoporosis Good correlation was obtained between the measured impedance and age 13