CardioInspect Diagnostic and Monitoring Systems for Congestive - - PowerPoint PPT Presentation

CardioInspect

Diagnostic and Monitoring Systems for Congestive Heart Failure (CHF) Patients

TAU Future Technology Development L.P.

The Technology

 EIT – Electrical Impedance Tomography

• Electrical Impedance tissue property is imaged

non invasively

 Chest belt with

disposable electrodes

Current Source Unit Voltage Measurement Unit Control and Acquisition Unit Reconstruction Algorithm

CardioInspect Standalone Prototype Clinical Trials

Clinical Results Monitoring Lung Edema Level

Edema Improvement

+35% +16%

Significant increase in resistivity values reflect improvement of lung fluid level

Lung Resistivity [Ohm*cm] Measurement #

The Telemedicine Home System

Recording Phase Transmitting Phase Clinical data as received at the medical center

The Telemedicine Home System

Healthy Subject CHF Patient

Confidential

Diagnostic and Monitoring EIT System for Osteoporosis

Confidential

Vision Statement

8

Revolutionize the diagnostics and monitoring of Osteoporosis in the clinic and at home by introducing an EIT based technology that can be integrated within a hand wristband

Confidential

Proposed Solution

9

Deliver a novel Electrical Impedance Tomography (EIT) based technology as an alternative to the DEXA solution:

• Inexpensive relative to other existing techniques
• Does not utilize ionizing radiation and well suited for long-term tracking

that is often required in Osteoporosis management

• Utilized using simple and compact hardware; Can be applied in small

clinics and at home

Current Source Unit Voltage Measurement Unit Control and Acquisition Unit Reconstruction Algorithm

Utilizing EIT:

• Provides information about the spatial electrical

conductivity distribution within the human body

• Based on applying small magnitude alternating

electric currents to the body and measuring developing electric potentials on the body surface

• The large variation in bone tissue electric and

dielectric properties during Osteoporosis, makes EIT a promising technique for monitoring and diagnosing

Confidential

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Technical Background (1 of 4)

Forward formulation - Calculation

• f the spatial electrical potential

due to known current sources and conductivity distribution

 

source source

J : conductor volume a in equations fields EM s Maxwell' by Solution J f              ) , (

Mathematical Formulation

Inverse formulation - Calculation of the spatial conductivity distribution due to known current sources and surface voltages

algorithm Raphson

• Newton

iterative by Solution ) , (   

surface source

J f 

Confidential

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Technical Background (2 of 4)

The Newton-Raphson algorithm

Initial Guess - 0 Forward Solver

Calculated surface potentials Measured surface potentials

Cost function

< yes End no k+1=k+k+1

Confidential

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Technical Background (3 of 4)

Displayed above are human body computerized model cross section results of the wrist and forearm as received from our preliminary numerical study, using a set of 5 electrodes on the surface of the wrist and measuring the surface potentials. Very strong correlation was found between the Impedance and BMD

Numerical computational simulation

Confidential

13

Technical Background (4 of 4)

Preliminary real measurements using the developed prototype

Results of 7 real tests from 5 healthy subjects and 2 patients with documented osteoporosis The prototype during measurement Good correlation was obtained between the measured impedance and age