Bundesamt fr Bevlkerungsschutz BABS LABOR SPIEZ Bundesamt fr - - PowerPoint PPT Presentation

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Bundesamt fr Bevlkerungsschutz BABS LABOR SPIEZ Bundesamt fr - - PowerPoint PPT Presentation

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Bundesamt fr Bevlkerungsschutz BABS LABOR SPIEZ Bundesamt fr Bevlkerungsschutz BABS LABOR SPIEZ SAB Response to the Director- Generals request to the SAB to provide further advice on CW sample stability and storage Dr Christophe

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Bundesamt für Bevölkerungsschutz BABS LABOR SPIEZ

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Bundesamt für Bevölkerungsschutz BABS LABOR SPIEZ

SAB Response to the Director-General’s request to the SAB to provide further advice on CW sample stability and storage

Dr Christophe Curty SAB Member SPIEZ LABORATORY 12.10.2016

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3 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Agenda

  • Background
  • DG’s request
  • What is known?
  • SAB response to the DG’s request
  • Conclusion
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4 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Background Facts

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Background Investigation & Sampling

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6 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Background Samples

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Background Analysis Results

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Background Overview: from the facts to the analysis

FACTS MISSION SAMPLES ANALYSIS RESULTS

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9 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

DG’s request, 02.11.2015: Storage & Stability?

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10 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

DG’s request, 02.11.2015: Storage & Stability?

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11 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

DG’s request, 02.11.2015: Storage & Stability?

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12 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

DG’s request, 02.11.2015: Storage & Stability?

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13 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

‘‘Credible results’’

«The SAB notes that the analytical findings of the Designated Laboratories (…) will always be scientifically accurate (…), the findings will always return ‘credible results’.»

  • OPCW Proficiency Tests
  • ISO 17025
  • National Accreditation
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Storage & Stability: what is known?

NATURAL PROCESS Degradation Rotting

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15 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Storage & Stability: what is known? Influenced by?

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16 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Storage & Stability: what is known? Influenced by?

  • Composition
  • Temperature
  • Packaging
  • Atmosphere
  • Duration
  • Light
  • Moisture
  • …
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17 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Storage & Stability : what is known? Chemistry

  • Chemical
  • Composition of sample
  • Temperature
  • Atmosphere
  • Packaging
  • Duration
  • Light
  • Moisture
  • …
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18 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

O P O H O

Storage & Stability: what is known? Chemistry

O P O O

CWA Sarin By-product Degradation

C l P C l O

O P C l O

F P F O

Preparation

O P F O

O H PO H O

NATURAL PROCESS

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19 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Storage & Stability: what is known? Chemistry

Concentration Time LOD A Degradation

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20 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Storage & Stability: what is known? Chemistry

Concentration Time LOD A Degradation

  • Chemical
  • Composition of sample
  • Temperature
  • Atmosphere
  • Packaging
  • Duration
  • Light
  • Moisture
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21 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Storage & Stability: what is known? Chemistry

Concentration Time Degradation A LOD

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Storage & Stability: what is known? Chemistry

Concentration Time A B Degradation A B LOD

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Storage & Stability: what is known? Chemistry

Concentration Time A B Degradation A B LOD 95 A 5 B 60 A 40 B 5 A 95 B T1 T2 T3

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24 Federal Office for Civil Protection FOCP SPIEZ LABORATORY 12.10.2016 Science for Diplomats

Storage & Stability: what is known? Chemistry

Concentration Time A B Degradation A B LOD 95 A 5 B 60 A 40 B 5 A 95 B T1 T2 T3

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Storage & Stability: what is known? Chemistry

O P F O O P O H O O H P O H O

O P O O

CWA Sarin By-product

C l P C l O

O P C l O

F P F O

Preparation CWC-related chemicals NATURAL PROCESS Degradation

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Storage & Stability: what is known? Chemistry

Chemical Weapons Convention Chemicals Analysis: Sample Collection, Preparation and Analytical Methods,

  • Ed. M. Mesilaakso, John Wiley & Sons, 2005.
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Storage & Stability: what is known? Chemistry

Cl S Cl O H S OH O H S OH O O H S OH O O

+

Cl As Cl Cl Cl As OH OH Cl As OH O OH Chemical Weapons Convention Chemicals Analysis: Sample Collection, Preparation and Analytical Methods,

  • Ed. M. Mesilaakso, John Wiley & Sons, 2005.

Cl N Cl O H N OH O H N

+

OH O

O P S N O O P OH S S H N O H P S N O S S N N

+

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Response to the DG’s request

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  • Review of > 180 scientific papers
  • Questionnaire to Designated Laboratories

Response to the DG’s request

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Executive Summary

Storage conditions at the OPCW Laboratory RT and 4°C

  • Always credible analytical results
  • Depends on many factors!
  • Hydrolysis, oxidation and polymerisation
  • Inevitable and natural (weeks to months!)
  • Reduce time between collection and analysis
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Executive Summary

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Executive Summary

Recommendations 3 to 8 Type of containers, extracts, biomedical samples, splitting

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Executive Summary

Recommendations 3 to 8 Type of containers, extracts, biomedical samples, splitting

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Executive Summary

Recommendations 3 to 8 Type of containers, extracts, biomedical samples, splitting

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Executive Summary

Recommendations 3 to 8 Type of containers, extracts, biomedical samples, splitting

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Executive Summary

Recommendations 3 to 8 Type of containers, extracts, biomedical samples, splitting

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Executive Summary

Recommendations 3 to 8 Type of containers, extracts, biomedical samples, splitting

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Executive Summary

  • Always credible analytical results
  • Inevitable and natural (weeks to months!)
  • Extend ‘‘life’’of original chemical
  • Chemical forensics
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Conclusion