Bone Cancer Research Trust Strictly Research Grant Applications - PowerPoint PPT Presentation

Bone Cancer Research Trust ‘Strictly Research’ Grant Applications 07/05/2016 BCRT 10 th Anniversary Conference CHARITABLE INCORPORATED ORGANISATION (CIO) NUMBER - 1159590

Safe surgical margins for Ewing Sarcoma R Craig, M Gibbons, N Athanasou, T Theologis Oxford Sarcoma Service/NDORMS

Study question If we were to plan our surgical resection for Ewing Sarcoma from the post-chemotherapy scan, would we still achieve a disease free margin?

Background – Ewing Sarcoma • 3 rd most common primary bone cancer • 1.5 per million • Predominantly affects teenagers and young adults • ~50% of cases affect the long bones of the arms and legs

Typical treatment pathway Neo-adjuvant Chemotherapy Surgery Radiotherapy Local control Adjuvant Chemotherapy

Surgery vs radiation • No randomised studies of surgery vs radiation • Current practice favours surgery for local control

What are our surgical goals? • Curative resection as part of multimodal treatment • Clear margins • Limb salvage surgery should not compromise survival • Must be as safe as amputation

Example reconstructions

Clinical case

Ewing Sarcoma: Responsive soft tissue mass Pre-chemotherapy Post-chemotherapy

Ewing Sarcoma: Responsive soft tissue mass Post-chemotherapy Pre-chemotherapy

Is there surgical consensus? Marginal vs More Radical Approach

Tidemark Tumour Oedema ? Healthy Tissue

Current evidence • No consensus on the required margin – global variation • Typical approach 2cm on pre-chemotherapy MRI margin • Survival not compromised if microscopically clear

Study Plan: Part 1: “Proof of Principle” • Retrospective review • Quantitative assessment of pre and post chemo imaging • MRI + PET where available • Confirm parameters for prospective study

Study Plan Part 2: Prospective study • Quantitative assessment of pre and post chemo imaging • MRI + PET where available • Histopathological analysis of selected resection levels • Actual operative margin • Measured resection from post-chemotherapy scan • Expect 2cm margin on pre and post chemotherapy scan

Resection from pre-chemo scan Resection from post-chemo scan Actual tumour margin Actual tumour margin Resection from post-chemo scan Resection from pre-chemo scan

Study Question “If we were to plan our resection based on the post-chemotherapy scan, would we achieve a disease free margin?”

Outcome measures • Is a 2cm margin based on a post-chemotherapy scan clear of tumour? • What is the difference between the actual length of resected bone and the new theoretical resection? • Would the reconstructive plan be changed by a more minimal resection?

What is the intended benefit? ↑ Limb sparing ↑ function Reduce resection ↑ Joint sparing volume ↓ reoperation ↑ Growth sparing Which requires safety data from our study

Timeline June 2016 July 2016-July 2018 End 2018 • Ethics approval • Prospective study • Completion of data analysis • Collect and analyzeretrospective • Aim to recruit 20 cases • Dissemination of results study data • Collaboration

Dissemination of results • BCRT • British OrthopaedicOncology Society • BOA – Tumoursection • Submission for open access publication in 2019 • The Bone and Joint Journal (or suitable alternative)

Key messages • Surgery is only a small part of overall management • Significant implications for long term function • Aggressive resection may limit the reconstructive options • More marginal techniques need to be assessed for safety

Meet The Team

Thank you Any Questions? R Craig, M Gibbons, N Athanasou, T Theologis