Amygdala lecture John OKeefe Amygdala interface between the - - PowerPoint PPT Presentation

▶
amygdala lecture john o keefe
SMART_READER_LITE
LIVE PREVIEW

Amygdala lecture John OKeefe Amygdala interface between the - - PowerPoint PPT Presentation

Aug 23, 2023 262 likes •634 views

Amygdala lecture John OKeefe Amygdala interface between the external world and the autonomic nervous system. Identifies stimuli which evoke emotions. May also be the primary area where activity is the neural correlate of emotional

slide-1
SLIDE 1

Amygdala lecture John O’Keefe Amygdala interface between the external world and the autonomic nervous system. Identifies stimuli which evoke

  • emotions. May also be the primary area where activity is the neural correlate of emotional experience.

Kluver-Bucy syndrome disturbances in visual perception disturbances in emotional/motivational behaviour aggression sexual behaviour feeding behaviour Anatomy of the Amygdala Basolateral Corticomedial Central nuclei Afferents and Efferents Amygdala function in animals Single unit sudies Fear conditioning Social Interaction Human lesion studies Case of SM - Loss of ability to recognise emotional expressions using visual or auditory cues Functional imaging studies Involvement in fear and perhaps anger and disgust

slide-2
SLIDE 2
slide-3
SLIDE 3

Kluver-Bucy Syndrome following bilateral temporal lobectomy in monkeys. Main components are: visual defects,

  • ral tendencies, and

changes in emotional behaviour (hypersexuality,hypo-emotionality)

slide-4
SLIDE 4

Basolateral Corticomedial Central

Primate amygdala Transverse sections

slide-5
SLIDE 5

Central nucleus visceral visceral

  • lfactory

Cortico- medial nuclei hypothalamus neocortex Basolateral nuclei dorsomedial nucleus of the thalamus Prefrontal cortex Input Amygdala nucleus Output

slide-6
SLIDE 6

Amygdala inputs and

  • utputs
slide-7
SLIDE 7
  • lfactory

input

slide-8
SLIDE 8
slide-9
SLIDE 9

visual input

slide-10
SLIDE 10
slide-11
SLIDE 11

Amygdala efferent-Stria Terminalis

slide-12
SLIDE 12

Amygala Eating Cells

Liu et al 2018

slide-13
SLIDE 13

Liu et al 2018

Habituation in Eating Cells

slide-14
SLIDE 14
slide-15
SLIDE 15

Amygdala cells are Specific Responsive 55% One Stimulus 61% Rat 40% Food 35% Transport Box 18%

slide-16
SLIDE 16

Other selective amygdala cells

slide-17
SLIDE 17

selective rat cells

slide-18
SLIDE 18

sec

active memory traces for eating rice

slide-19
SLIDE 19

active memory traces for experience

  • f exploring

transport box

slide-20
SLIDE 20

active memory traces are independent of behavior

slide-21
SLIDE 21

Pavlovian fear conditioning

slide-22
SLIDE 22

Nuclei involved in conditioned fear and their autonomic and behavioural actions

slide-23
SLIDE 23
slide-24
SLIDE 24

Effect of amygdala lesions on social behavior

slide-25
SLIDE 25
slide-26
SLIDE 26

affiliative vocalizations towards mother/infant pairs are reduced by amygdala lesions

slide-27
SLIDE 27

Ekman Emotional faces

slide-28
SLIDE 28

Ekman Emotional faces

slide-29
SLIDE 29

electrode placements in temporal lobe

slide-30
SLIDE 30

human amygdala cell responding to emotion

  • f surprise
  • n faces
slide-31
SLIDE 31

Mormann 2011

right human amygdala cells responding to pictures

  • f animals
slide-32
SLIDE 32

SM’s Missing amygdala

slide-33
SLIDE 33

S.M’s drawings

  • f

emotions

slide-34
SLIDE 34
slide-35
SLIDE 35
slide-36
SLIDE 36

Bilateral amygdala activation from threatening words