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Feb 18, 2023 177 likes •306 views

Academia: no learning without knowledge, no knowledge without learning TRPC6, NEP Van den Berg, Weening et al., 2004 Pathology of Idiopathic Membranous Glomerulopathy Subepithelial electron dense deposits Injury of epithelial cells

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Academia: no learning without knowledge, no knowledge without learning

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Van den Berg, Weening et al., 2004 TRPC6, NEP

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Pathology of Idiopathic Membranous Glomerulopathy

Subepithelial electron dense deposits
Injury of epithelial cells leading to

dedifferentiation

Formation of spikes with novel matrix

components (Abrahamson et al)

Staging (Black)
Configuration of the deposits (patterns, density,

synchrony, hump-like)

Immunoglobulin isotypes (IgG1 & 4)
Complement binding and activation
Antigen specificity
Transcription studies
Proteomic studies

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Pathology of Idiopathic Membranous Glomerulopathy Prognostic factors (Troyanov, Cattran et al; KI,

2006; 69:1641-1648)

1. Signs of chronicity in the biopsy (vascular

sclerosis, FGS, tubulointerstitial injury)

2. Complement deposition
3. Stage and synchrony of deposits

Ad #1: older patients; reduced renal survival but not independent from clinical variables; no correlation with rate of decline; and: did not preclude a remission in proteinuria upon immunosuppressive treatment Ad #2 and #3: did not predict renal survival; however #3 did correlate with the rate of progression.