Academia: no learning without knowledge, no knowledge without - PowerPoint PPT Presentation

Academia: no learning without knowledge, no knowledge without learning

TRPC6, NEP Van den Berg, Weening et al., 2004

Pathology of Idiopathic Membranous Glomerulopathy • Subepithelial electron dense deposits • Injury of epithelial cells leading to dedifferentiation • Formation of spikes with novel matrix components (Abrahamson et al) • Staging (Black) • Configuration of the deposits (patterns, density, synchrony, hump-like) • Immunoglobulin isotypes (IgG1 & 4) • Complement binding and activation • Antigen specificity • Transcription studies • Proteomic studies

Pathology of Idiopathic Membranous Glomerulopathy Prognostic factors (Troyanov, Cattran et al; KI, 2006; 69:1641-1648) 1. Signs of chronicity in the biopsy (vascular sclerosis, FGS, tubulointerstitial injury) 2. Complement deposition 3. Stage and synchrony of deposits Ad #1: older patients; reduced renal survival but not independent from clinical variables; no correlation with rate of decline; and: did not preclude a remission in proteinuria upon immunosuppressive treatment Ad #2 and #3: did not predict renal survival; however #3 did correlate with the rate of progression.