A Dusky Hypoxic Woman Craig Smollin MD Associate Medical Director - - PDF document

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Sep 23, 2023 201 likes •417 views

A Dusky Hypoxic Woman Craig Smollin MD Associate Medical Director California Poison Control Center - SF Div. Blue man case #1 A 46 year-old male was sent to the emergency department for cyanosis. In the emergency department he appeared in

SLIDE 1

A Dusky Hypoxic Woman

Craig Smollin MD Associate Medical Director California Poison Control Center - SF Div.

SLIDE 2

Blue man case #1

A 46 year-old male was sent to the

emergency department for cyanosis. In the emergency department he appeared in no acute distress and had

bvious blue-gray discoloration of the
skin. Vital signs were BP 148/81, P 88,

RR 16, O2 sat 98%, Temp afebrile. The rest of the exam is unremarkable.

Blue man case #2

A 34 year old HIV+ woman presents

with c/o feeling lightheaded, nauseated, and short of breath. Vital signs were BP 124/88, P 116, RR 18 , O2 sat 82% NRB, Afebrile. She was in no respiratory distress but appeared to have blue discoloration of the lips, gums, face and peripherally in the digits and nail beds. The rest of the exam was unremarkable.

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What is cyanosis?

Blue discoloration due to hypoxemia.
Central vs. peripheral
First visible on lips and tongue.
Deoxygenated hgb = 3.5 g/dL in arterial

blood.

O2 sat 73-78%
Cyanosis is an unreliable sign of

hypoxemia. Cyanosis unreliable sign of hypoxemia

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Cyanosis unreliable sign of hypoxemia Cyanosis unreliable sign of hypoxemia

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Approach to the blue patient Blue man case #1

A 46 year-old male was sent to the

emergency department for cyanosis. In the emergency department he appeared in no acute distress and had

bvious blue-gray discoloration of the
skin. Vital signs were BP 148/81, P 88,

RR 16, O2 sat 98%, Temp afebrile. The rest of the exam is unremarkable.

SLIDE 6

Blue man case #1

A 46 year-old male was sent to the

emergency department for cyanosis. In the emergency department he appeared in no acute distress and had

bvious blue-gray discoloration of the
skin. Vital signs were BP 148/81, P 88,

RR 16, O2 sat 98%, Temp afebrile. The rest of the exam is unremarkable.

ABG: 7.45, PCO2 35, PO2 133, lactate

1.8

What is the diagnosis?

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Blue man case #1

On further questions the patient admits

to the use of colloidal silver for the treatment of chronic MRSA infection of the skin. He purchased the product

ver the internet and has been using it

regularly over the past year. During that time, he has noticed a gradual change in his skin color to the current blue-gray appearance.

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Argyria Blue man case #2

A 34 year old HIV+ woman presents

with c/o feeling lightheaded, nauseated, and short of breath. Vital signs were BP 124/88, P 116, RR 18 , O2 sat 82% NRB, Afebrile. She was in no respiratory distress but appeared cyanotic in the lips, gums, face and peripherally in the digits and nail beds. The rest of the exam was unremarkable.

SLIDE 9

Blue man case #2

A 34 year old HIV+ woman presents

with c/o feeling lightheaded, nauseated, and short of breath. Vital signs were BP 124/88, P 116, RR 18 , O2 sat 82% NRB, Afebrile. She was in no respiratory distress but appeared cyanotic in the lips, gums, face and peripherally in the digits and nail beds. The rest of the exam was unremarkable.

ABG = 7.44, PCO2 31, PO2 307,

Lactate 1 0

Approach to the blue patient

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Blue man case #2

A 34 year old HIV+ woman presents

with c/o feeling lightheaded, nauseated, and short of breath. Vital signs were BP 124/88, P 116, RR 18 , O2 sat 82% NRB, Afebrile. She was in no respiratory distress but appeared cyanotic in the lips, gums, face and peripherally in the digits and nail beds. The rest of the exam was unremarkable.

ABG = 7.44, PCO2 31, PO2 307,

Lactate 1.0

MetHb = 41%

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Common drugs and toxins causing methgb

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Met-hgb Pathophysiology

Hemoglobin Oxygen

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Met-Hgb

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1. Functional Anemia
2. Shift in Oxygen Hgb

Dissociation Curve

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40 80 120 50 100

Oxygen Partial Pressure (mmHg) Percent Saturation Hgb

40 80 120 50 100

Oxygen Partial Pressure (mmHg) Percent Saturation Hgb alveoli

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40 80 120 50 100