1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS 1 CONCEPT - - PowerPoint PPT Presentation

1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS

1 CONCEPT SINGLE TOPICAL PRODUCT

1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS

Lipophilic phase protects the active principles of the formulations from

• xidation. At the same time it has a

moisturizing and filming activity, and contributes to cutaneous hydro- lipidic film Hydrophilic phase contains an innovative mixture of TCA, AHA,BHA, PHA, aminoacids and vitamins. It performs a deep biostimulating and revitalizing action, beyond the expected peeling effect

Why the BIPHASIC TECHNOLOGY in BioRePeelCl3is important? Who commonly uses TCA medical devices knows very well the negative issues concerning theproducts:

Unstable products Darkening Preservation in fridge Oxidation and denaturation

• Liphophilic

phase floats on hydrophilic phase preventing the contact with the oxygen inside the bottle

• The mechanic barrier stabilizes the hydrophilic

phase: TCAand other active ingredients does not

• xidize
• Density difference of the two phases guarantees a

constant protection even after shaking

How the BIPHASIC TECHNOLOGY works:

Biphasic formulation advantajes ofBioRePeelCl3 : Room temperature stability No TCA oxidation No formulation darkening anddegradation Funcionalized liphophilic phase

1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS

BIO R E

P E E L

LIPO

COMPLEX

4 FUNCTIONALCOMPLEXES

GL YCINE Glycine is the most abundant aminoacid in collagen (35%). It hasmoisturizing, antioxidant and regeneratingproperties. PROLINE Basic aminoacid in collagen synthesis and support. It has elasticizing properties so it is indicated for inelastic and aged skin. HYDROXYPROLINE Hydroxyproline is widely present in collagen. It increases and support ceramides synthesis, activating keratinocytes proliferation and fibroblasts’ collagenproduction. VITAMIN C Essential cofactor in collagen synthesis. It is the main cellular antioxidant molecule. It protects from R O S(Reactive Oxygen Species)and regenerate other antioxidant molecules.

Gamma-aminobutyricacid (GABA) It is a non essential aminoacid and the chief inhibitory neurotransmitter in the mammalian central nervous system. It promotes collagen synthesis thanks to inhibition of cutaneous Metalloproteinases (MMPs), cutaneous proteins degradation enzymes1. The GABAeffect is cutaneous tissue distension thanks to nerve relaxation and consequent relaxation of the muscles responsible of wrinkling. The result is an effective anti-wrinkle action.

1)Effectsof GABAon the expression of type I collagen gene in normal human dermal fibroblasts. Uehara E1, Hokazono H1, Sasaki T2, Y

• shioka H2, Matsuo N2

ARGININE Arginine is a basic aminoacid with moisturizing and trophic functions for the skin. It is involved in blood flow regulation processes. It helps regulating biochemical processes like protein and macromolecule synthesis as collagen, elastin and keratin. Indicated for inelasticskin. It is a biochemical modulator of trichloroacetic acid and the fundamental substrate for NOproduction. It promotes angiogenesis, cutaneous riepithelialization and tissue growth factors production.

2)Proliferative, anti-apoptotic and immune-enhancing effects of L-arginine in culture

• f skinfibroblasts.Kocic H1, Arsic I2, Stankovic M2, Tiodorovic D3, Ciric V4, Kocic G5.

3)Administration of L-arginine reducesthedelayof the healing processcausedby ibuprofen. Implication of COX and growth factors expression.Sánchez-Fidalgo S

1, Martín-Lacave I, Illanes

M, Bruseghini L, Esteras A, Motilva V.

4) Riboflavin and health: A review of recent humanresearch. Thakur K1, T

• mar SK1, Singh AK2, Mandal S

1, Arora S 3

RIBOFLAVIN

Riboflavin, also known as Vitamin B2, is an hydrophilic vitamin, necessary for normal skintropism. It is F AD and FMN precursor, so it is involved in huge number of metabolic reaction, as the activation of other vitamins. It helps removing ROSdue to cutaneous oxidative stress and it canaccelerate cell growth andregeneration. Thedeficiency generates afunctional alteration of the skin with afine-grained and greasyskin4.

TRICHLOROACETIC ACID It is a carboxylic acid with exfoliating action and indirect revitalizing action. When applied on the skin, it makes epidermal protein precipitate and denaturate; this process is defined keratocoagulation. The level

• f

penetration depends

• n

substance concentration. It performs its action through a three-step biochemical cascade, activating a specific endocrine system of the skin.

Biochemical cascade trichloroacetic acid induced5: 1)Activation of pre-inflammatory in response tochemical acidic stress; 2) Activation of Skin Stress Response System POMC- induced (proopiomelanocortin); 3) Growth factor production in response tochemical stress.

Inflammation IL-1 →IL-10 S S R S POMC → MC-1R Proliferation P DGF VE G F TGF-β1 T G F-α

5) Influence of trichloroacetic acid peeling on the skin stressresponsesystem. Kimura A1, Kanazawa N, Li HJ, Y

• nei N, Yamamoto Y

, FurukawaF .

LACTOBIONIC ACID This product is made of a molecule of gluconic acid, a poly-hydroxyacid, linked to acarbohydrate,galactose. It is an effective epidermal antiageing molecule and stimulates dermal matrix polymer synthesis and dermal synthesis6. It reduces cutaneous Metalloproteinases (MMPs) production, protecting the skin from chronoageing and photoageing7. Galactose is an endogen carbohydrate that is used by fibroblasts to synthesize glycosaminoglycans and collagen.

6) Clinical uses of hydroxyacids. Zoe DianaDraelos 7) Lactobionic Acid - a Novel Polyhydroxy Bionic Acid forSkincare. Green AB, Wildnauer HR, EdisonLB

SALICYLICACID It is a beta-hydroxyacids and powerful keratolytic, that selectively cuts keratin aminoacidic chain ofcorneocytes. It doesn’t affect the other dermal proteins, so it exerts the exfoliating action only on dermal protein, making this active principle well tolerated by cells below, void of keratin. It has bacteriostatic and lenitive actions, frees the enlarged pores from the sebaceous content, creating an unfavorable environment for bacterial growth and thus reducing the possibility of formation of acne lesions.

T ART ARICACID acid and a powerful antioxidant for its lightening and exfoliating It is a dicarboxylic molecule, famous properties. It is used for the keratolytic action, it reduce corneocytes

• adesion. It is effective to treat dry, inelastic skin, acne

and blackheads. CITRICACID It is a tricarboxylic acid, with chelating properties for bivalent ions like Ca2+; this is a reason why the acid has antioxidant action. The hydroxyl group in alfa-position of carboxylic group gives exfoliating and keratolytic properties. It also has regenerating and astringent effects for enlargedpores.

1 CONCEPT 2PHASES 4 FUNCTIONALCOMPLEXES 9ACTIONS

PROTECTIVE AND ST ABILIZINGACTIONS It prevents trichloroacetic acid and other active principles Oxidation, improving performances and product safety. FILMING AND VEHICULA TINGACTIONS It reduces trans-epidermic water evaporation and assists active principles vehiculation. REGENERA TINGACTION It restores and maintains cutaneous hydro-lipidic film. MOISTURIZINGACTION It increases hydration through direct and indirect mechanism. BIOSTIMULATING ACTION It stimulates fibroblasts' activity and activates cutaneous proliferating and biosynthetic processes. REVIT ALIZING ACTION It increases cellular turnover and production of collagen, elastin and hyaluronic acid. PEELING AND KERA T OL YTICACTIONS It removes outer cells of stratum corneum by breaking corneocytes adesion bonds. ANTI-WRINKLE AND ANTIOXIDANTACTIONS It reduces fine lines by neutralization of free radicals. ANTIACNE – COMEDONES – ENLARGED PORES It helps battle against acne, it eliminates comedones and it has an astringent effect on enlarged pores.

T R E A TMENTS

TCA 35% pHA Lactobionicacid βHA Salicylicacid HA T artaric acid, Citricacid AMINOACIDS Glicine, Proline, Hydroxyproline,Arginine VITAMINS Vitamin C, Vitamin B2 LIFTING ACTIVE PRINCIPLE:GABA LIPOPHILIC PHASE: Squalane, Isopropyl myristate 6 mL x 5 vials

Face - Neck - Decolletè

Face - Neck - Decolletè

T0 T1 T2 T3 Tn 7-10 days 7-10 days 7-10 days 7-10 days T1 T2 T3 Tn

3 MONTHS

7-10 days 7-10 days 7-10 days

RECALL PROTOCOL

TCA50% pHA Lactobionicacid βHA Salicylicacid HA T artaric acid, Citricacid AMINOACIDS Glicine, Proline, Hydroxyproline,Arginine VITAMINS Vitamin C, Vitamin B2 LIFTING ACTIVE PRINCIPLE:GABA LIPOPHILIC PHASE: Squalane, Isopropyl myristate 12 mL x 3 vials

Hands – Elbows – Glutes – Knees - Feet

Hands – Elbows – Glutes – Knees - Feet

T0 T1 T2 T3 Tn 10-15 days 10-15 days 10-15 days 10-15 days T1 T2 T3 Tn

3 MONTHS

10-15 days 10-15 days 10-15 days

RECALL PROTOCOL

SHAKE BEFORE AFTER SHAKE

ADV ANT AG E S

KIND OFTREATMENT WHEN INJECTIVETREATMENTS Before PHOTOSTIMULATION Before RADIOFREQUENCY After TOPICALTREATMENT Before

ASSOCIATIONS

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