TETRODOTOXIN Hannah Gallovic ECE 4910 (TTX) May 4, 2016 Symptoms - - PowerPoint PPT Presentation

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Dec 05, 2022 140 likes •188 views

TETRODOTOXIN Hannah Gallovic ECE 4910 (TTX) May 4, 2016 Symptoms Exposure Numbness, facial and limb paralysis, Found in sex organs of fish, headache, abdominal pain, dizziness amphibians, octopi, and shellfish Na channels immune to TTX

SLIDE 1

TETRODOTOXIN (TTX)

Symptoms

Numbness, facial and limb paralysis, headache, abdominal pain, dizziness Paralysis in main muscles, respiratory problems, irregular heart beat, seizure, death

Exposure

Found in sex organs of fish, amphibians, octopi, and shellfish

 Na channels immune to TTX

Food contamination Eating raw fish Fatal dose: 1 mg

Hannah Gallovic ECE 4910 May 4, 2016

SLIDE 2

EFFECTS ON THE NERVOUS SYSTEM

Guanidino group on TTX binds to carboxylate group on Na channels Blocks Na channels, eventually stopping INa altogether

Action potentials cease to fire Stops signals traveling from nerves to muscles

SLIDE 3

REFERENCES

http://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html http://www.life.umd.edu/grad/mlfsc/zctsim/ionchannel.html