TETRODOTOXIN Hannah Gallovic ECE 4910 (TTX) May 4, 2016 Symptoms - PowerPoint PPT Presentation

Dec 05, 2022 •140 likes •182 views

TETRODOTOXIN Hannah Gallovic ECE 4910 (TTX) May 4, 2016 Symptoms Exposure Numbness, facial and limb paralysis, Found in sex organs of fish, headache, abdominal pain, dizziness amphibians, octopi, and shellfish Na channels immune to TTX

TETRODOTOXIN Hannah Gallovic ECE 4910 (TTX) May 4, 2016 Symptoms Exposure Numbness, facial and limb paralysis, Found in sex organs of fish, headache, abdominal pain, dizziness amphibians, octopi, and shellfish  Na channels immune to TTX Paralysis in main muscles, respiratory problems, irregular heart beat, Food contamination seizure, death Eating raw fish Fatal dose: 1 mg
EFFECTS ON THE NERVOUS SYSTEM Guanidino group on TTX binds to carboxylate group on Na channels Blocks Na channels, eventually stopping INa altogether  Action potentials cease to fire  Stops signals traveling from nerves to muscles
REFERENCES http://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html http://www.life.umd.edu/grad/mlfsc/zctsim/ionchannel.html

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