PGx Test: A Life Saver Personalized Medicine for Everyone Current - - PowerPoint PPT Presentation

PGx Test: A Life Saver

“Personalized Medicine for Everyone”

Current Prescriptions

“Take this, if it doesn’t work, we’ll try something else.”

TRADITIONAL TREATMENT

Traditional testing results in a “one size fits all” approach with a population of patients suffering adverse drug events,

• r not responding to the medication.

TRADITIONAL TREATMENT

Genetic Variations

The number of people who die in America because of Adverse Drug Reactions (ADR’s) is equivalent to a large aircraft crashing every day resulting in 300 deaths! That’s over 100,000 per year!

“One in six hospital admissions of

• lder adults is

because of an adve vers rse e dru rug eve event…”

Because se of

• f th

these se fa factor

• rs,

s, doc

• ctor
• rs

s are co concern rned ed which prescription medications…

➢ Will l work rk best; t; ➢ Will l work rk least; ➢ Will l not work; rk; ➢ The dosag age amoun

• unt;

t; ➢ Might ght cause use harmful rmful side effect fects; s; ➢ May have ve catas astro trophic phic inter erac actions. ions.

What if there was a test that would…

Eliminat nate e this guesswor work by by giving ng doctors

• rs the

right informa rmation ion to prescri cribe be the right t medicat cation, ion, in the right dosag age, e, at the right t time, to all their patie ients? s?

Welcome to…

The he New New Frontier

• ntier
• f
• f P

Per ersonaliz sonalized ed Medicine Medicine thr through DN

• ugh DNA

A Testing! esting!

Personalized Drug Therapy with Pharmacogenetics DNA Testing

Orga gani nizat ation ions s ad adoptin ing g Ph Phar arma maco coge genetic netic tes estin ing

∙ Ma

Mayo

• Clinic

ic

∙ Vander

derbi bilt lt Univer ersi sity y Me Medi dical cal Center er

∙ Jo

Johns hns Hopkin Hopkins Me Medi dica cal Center er

∙ Duke Medical

Medical Center er

∙ Hos

Hospit pital al Corpor rporat ation ion of

• f Amer

erica ica

∙ St. Jude’s Children’s Hospital

Wh Why y Sho houl uld d Ph Phys ysic ician ians s Tes est the their ir P Pat atie ients?

Doctors testing patients ENHANCES Pharmac rmacog

• genet

netic c testing ELIMINATES

➢ Pa Patient t Care, , Satisf sfacti action

• n and Conf

nfide idenc nce ➢ Complianc iance

➢ Trial and error prescr crip iptions

• ns

➢ Common “One Size Fits All” medication management ➢ Guesswo work

Calls it…

“Future of Medicine”

Call it…

“Precision Prescription”

Columbia University Cornell University

Doct ctors

• rs obt

btai ain n a ver very y simple ple Pharmac armacog

• gene

eneti tic c cheek eek swa wab sample, ple, righ ght t in the of

• ffi

fice. ce.

How i

• w is th

the t test st co cond nduc ucted? ed?

➢ Me

Medi dica care usual ally ly pays s for r it, as we well as many y oth

• ther

er insur uran ance ce compa mpanies nies

➢ One-time

ime, lifet etime me test st

➢ We NEVER

VER balance ance bill the patien ent

Ri Right Informa mation, ion, Ri Right Drug, g, Ri Right Dose, se, Ri Right fr from m the beginni ning ng.

CYP 450 Metabolizer Types…

METAB ABOL OLIZE IZER

DRUG

UG METAB ABOLISM ISM

Po Poor

• r Met

etabol bolize izer r (PM) ) No None or ve very y low

• w

In Inter ermediat mediate e Met etaboli bolizer er (IM IM) Red educed ced Excelle lent Met etabol bolize izer r (EM) No Normal rmal Ultra-Rapi pid d Met etabol bolize izer r (UM) ) Increased ased

With PGxOne™ testing physicians are provided with clear, clinically actionable recommendations, allowing them to select the optimal drug at the best dose for each patient.

Pharmacogenomics Testing

Info formati rmation

• n is like a privat

vate, e, indivi viduali dualized zed consult ltation ation

➢ Discus usses ses your r gene netic tic make-up p and how your r body respon ponds ds to differ ferent t medic icatio ations ns ➢ Predicts icts drug – drug interact ractio ions ns with recomm commend ndatio ations ns for altern rnativ atives

Informa matio tion n give ves s peace e of mind d for patient ents and physic icia ians ns

➢ Impro roved ved patient nt health th ➢ Impro roved ved patient nt comp mpli lianc nce ➢ Bette tter r outc tcomes mes ➢ Reduc uced d liabili lity ty

Vital l informat

• rmation

ion is deliver ered ed qui uick ckly ly to the doctor’s office

Th That at Beg Begs t the Qu he Ques estio ion: n:

Is t s there re any re reaso son a d doc

• ctor
• r wo

wouldn't n't use the test, since…

1) 1)

It can decr creas ase e adve verse rse drug ug react actions; ions;

2) 2)

It’s quick and easy to administer;

3) 3)

It can lower the doctor’s liability;

4) 4)

Patients ients want t it (in fact, ct, may demand mand it)!

Practitioners who have patients who:

✦ Have multiple drug types prescribed ✦ Are taking medications with black box warnings that recommend PGx testing. ✦ Are taking medications related to risk for Thrombosis (Blood clot). ✦ Have a history of poor medication compliance. ✦ Poor compliance is associated with significant morbidity, mortality and health-care costs.

Wh Who N Nee eeds ds Th This is Tes est U Urge gently ly?

Practitioners who have patients who:

✦ Have multiple chronic conditions ✦ Require a higher-than-standard dosage to achieve the desired result ✦ Have had a severe adverse drug reaction ✦ Have had unexpected or unexplained responses to medications ✦ Have had multiple unsuccessful drug trials ✦ Have health issues in multiple organ systems

Wh Who N Nee eeds ds Th This is Tes est U Urge gently ly?

Cur urrent ent Us Usag age

It is estimated ted that less than 6% of f doctor tors are current rently y off fferi ering ng the e phamacog macogene enetic ic tes est to their patients ents. Yet et, in 2-3 ye years s is s will bec ecome me routi utine ne and patients will ‘demand it’.

If inf infor

• rmat

mation ion is th there to i e to imp mprove

• ve

pa pati tient ca nt care, why , why no not ma t make ke a pa part of t of your ‘Standard Care’?

Wh Who Do Y

• Do You K
• u Know?

now?

Do i Do it No t Now, w, or

• r

Do i Do it La t Later ter It’s going to happen Dem Demand and the the PG PGx Te x Test st TO TODAY DAY!

• In today's world, only 30-60% of drugs work effectively to rid

a patient's illness.

• However, with the application of pharmacogenomics, the

success rate of drugs will increase to 100% (responders)

Pr Pres escr crip iption tion Dr Drugs No L

• Lon
• nger

r a G Guessi ssing ng Game me!

What Can We Do So That Everyone Responds Well To Treatment?

Q&A Q&A