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Penn Acute Research Collaborative (PARC) Interdepartmental clinical and translational research at Penn Presbyterian Medical Center Benjamin S. Abella, MD Mphil Carrie A. Sims, MD, MS Joshua Levine, MD Clinical research vignette Sunday, 2 AM:

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  1. Penn Acute Research Collaborative (PARC) Interdepartmental clinical and translational research at Penn Presbyterian Medical Center Benjamin S. Abella, MD Mphil Carrie A. Sims, MD, MS Joshua Levine, MD

  2. Clinical research vignette Sunday, 2 AM: Pt resuscitated from cardiac arrest; transferred to MICU Post-arrest care bundle initiated Clinical research team member notified; patient screened remotely and meets enrollment criteria for NHLBI R01 study Blood draw with sample prep is required within 90 min of arrest to satisfy enrollment Clinical team busy saving lives Only family for possible consent - R01: Hyperoxia during distraught son, unknown post-arrest care power-of-attorney status 2

  3. Challenges inherent in Acute Care Research (ARC) A number of major barriers serve to limit ACR: Logistical: Clinical events occur 24/7 and without warning; immediate response required Cost/efficiency: Full-time staffing for infrequent events cost prohibitive and inefficient Specialized training: Issues surrounding rapid consent, often by proxy; interactions with clinical team Coordination: Infrequent patients often qualify for multiple studies across research silos 3

  4. Timely opportunity to address this issue Chance to bridge silo structures and build new collaborative approach HUP Emergency Trauma Neurology Medicine Surgery ACR ACR ACR “Together, We are Stronger” ? 4

  5. PARC initiative: Specific Aims Responsive to Penn Medicine Strategic Plan 2013-2017 Aim 1. Establish a broad, multidisciplinary faculty group to foster acute care research collaboration and new project proposals. Aim 2. Implement a 24/7 research staff program to support acute care research projects and serve as an attractive infrastructure to support funding proposals to federal and other sources. Aim 3. Develop a collaborative translational laboratory space. Aim 4. Develop collaborative translational projects in order to understand the mechanistic underpinnings of acute care conditions and subsequent pathophysiology. 5

  6. PARC Multidisciplinary Support  University of Pennsylvania School of Medicine  Surgery  Neurosurgery  Neurology  Emergency Medicine  Medicine  Orthopedics  Anesthesia  Physical Medicine and Rehabilitation 6

  7. PARC Organization Leadership structure Investigators SOM research structures Advisory Board SOM Departments, IRB, ORS, CTT industry partners, Penn BioBank Steering Committee contracted research Penn datastore Human Subjects Division Translational Laboratory Education and Division Informatics Division Medical director (Abella) Laboratory director (Sims) Educational director (Levine) data manager Research coordinators Laboratory technicians liaison to Penn data store aaaaa 7

  8. What can PARC do for you?  Research design - clinical and translational  Assay consultation and 24/7 lab access  Regulatory support  ACR 24/7 coverage for screening, enrollment, consent, data collection, sample processing  Small grants 8

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