SLIDE 2 Theoretical advances New & better algorithms Open source software
Challenges for optimization Solution methodology Physician training Relevant scenarios Challenges for optimization Solution methodology
Decision support systems Simulators for diseases A L G O R I T H M S C L I N I C A L P R A C T I C E
MODEST: Mathematical Optimization for clinical DEcision Support and Training
Sebastian Sager, Magdeburg, Germany
Personalized medicine via optimization
Simulation: warnings and alerts what would happen if...? Optimization: fit models to patient data get patient-specific treatment get patient-specific diagnosis e.g., for cardiac arrhythmia Probability for Atrial Fibrillation: 85% Probability for Atrial Flutter: 93%
Clinical decision training
Simulation: Optimization: what would happen if... ? what would be best?
Mixed-integer nonlinear optimal control
Uncertainties, e.g., model-plant mismatch patient-specific parameters Integrality, e.g., which combination of drugs? Wenckebach or Mobitz block? Global optima needed MI(N)OCP MI(L)OCP OCP&MILP NLP&MILP MINLP MINLP OCP NLP
convexification discretization discretization relaxation discretization discretization relaxation initialization
OCP
Switching Time Optimization discretization
NLP
adaptive grid refinement