Myopia Exploring the genetic & functional basis Myopia - PowerPoint PPT Presentation

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Myopia Exploring the genetic & functional basis Myopia Refractive error Increased incidence, myopia boom Permanent severe visual impairment and blindness Multifactorial disease Environmental factors Near work

Myopia Exploring the genetic & functional basis • Myopia • Refractive error • Increased incidence, “myopia boom” • Permanent severe visual impairment and blindness • Multifactorial disease • Environmental factors • Near work and time spent outdoor
Myopia Exploring the genetic & functional basis • Genetic variations identified in GWAS • Tedja et al, 2018, Nature
Myopia Exploring the genetic & functional basis • Functional analysis of the identified genes • Knockout mouse models: GJD2 • Biometry: refractive error, corneal curvature, axial length • Behavioral: optokinetic response • Retina: electroretinography • (Expression levels: related proteins) • Interplay with environmental factors • Lighting conditions, contrast

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