Myopia Exploring the genetic & functional basis Myopia - - PowerPoint PPT Presentation

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myopia exploring the genetic amp functional basis

Dec 30, 2023 236 likes •297 views

Myopia Exploring the genetic & functional basis Myopia Refractive error Increased incidence, myopia boom Permanent severe visual impairment and blindness Multifactorial disease Environmental factors Near work

SLIDE 1

Myopia Exploring the genetic & functional basis

Myopia
Refractive error
Increased incidence, “myopia boom”
Permanent severe visual impairment and blindness
Multifactorial disease
Environmental factors
Near work and time spent outdoor

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Genetic variations identified in GWAS
Tedja et al, 2018, Nature

Myopia Exploring the genetic & functional basis

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Functional analysis of the identified genes
Knockout mouse models: GJD2
Biometry: refractive error, corneal curvature, axial length
Behavioral: optokinetic response
Retina: electroretinography
(Expression levels: related proteins)
Interplay with environmental factors
Lighting conditions, contrast