Metallurgical and Materials Engineering of COPPE/UFRJ: from 1967 to - - PowerPoint PPT Presentation

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Metallurgical and Materials Engineering of COPPE/UFRJ: from 1967 to - - PowerPoint PPT Presentation

Nov 08, 2023 428 likes •622 views

Metallurgical and Materials Engineering of COPPE/UFRJ: from 1967 to Biomaterials Gloria de Almeida Soares Mecnica, Materiais Avanados e Nanotecnologia Metallurgical and Materials Department Academic Staff: 31 Technical &

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‘Mecânica, Materiais Avançados e Nanotecnologia’

Metallurgical and Materials Engineering

  • f COPPE/UFRJ:

from 1967 to Biomaterials

Gloria de Almeida Soares

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‘Mecânica, Materiais Avançados e Nanotecnologia’

  • Teaching (undergraduate and graduate levels)
  • M.Sc. and Ph.D. Projects
  • Cooperative Research and Exchange
  • Technological Projects, Evaluations and

Consulting Services

Academic Staff: 31 Technical & Administration Staff: 27 Metallurgical and Materials Department

2001-2003: ≈ US$ 4 million

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‘Mecânica, Materiais Avançados e Nanotecnologia’

Research Facilities ≈ 2,500 m2

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‘Mecânica, Materiais Avançados e Nanotecnologia’

ACADEMIC RESULTS

Graduates degrees more than 600 (up to dec. 2003) PERIOD M.Sc. Ph.D. TOTAL 1967-1997 363 52 415 1998-2000 79 30 109 2001-2003 73 40 113

TOTAL 515 122

637

Undergraduate: more than 600 (Metal. & Materials)

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‘Mecânica, Materiais Avançados e Nanotecnologia’

Research Groups:

  • Mineral Processing and Extractive metallurgy
  • Thermomechanical processing and microstructural eng.
  • Physical metallurgy and mechanical properties
  • Welding and non-destructive testing
  • Corrosion
  • Surfaces and thin films
  • Advanced ceramics
  • Biomaterials
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‘Mecânica, Materiais Avançados e Nanotecnologia’

BIOMATERIALS: Start: 1995 Academic results: 24 M.Sc and 6 D.Sc.

Research Themes:

  • Materials for bone-substitution: Development of porous and

granular hydroxyapatite -based materials. Hydroxyapatite- based composites.

  • Materials for implants: surface treatments on titanium and

titanium alloys. Bioactive coatings.

  • Correlation between properties and microstructure on dental

ceramics.

  • Corrosion of metallic alloys.
  • Polymer and Composites for Restorative Function.
  • Failure analysis on dental restoration
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‘Mecânica, Materiais Avançados e Nanotecnologia’

characterization of commercial CaP granules

Materials for bone-substitution: Calcium Phosphate (CaP) Materials

Bone graft Scaffold for cell therapy Carriers for drug delivery

multiphase, micro or macroporous granules or tablets hydroxyapatite-collagen composites Zn-containing hydroxyapatite

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‘Mecânica, Materiais Avançados e Nanotecnologia’

  • 1. Commercial granules

Conz, M.B., 2003

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‘Mecânica, Materiais Avançados e Nanotecnologia’

  • 2. CaP porous tablets

2 4 6 8 10 12 14 16 18 20 22 24 >400 30 0-400 200-300 100-200 <100

P ORE DIST RIBUTION (%) (m easured by im age analysis) RANGE OF PORE SIZE (µ m)

20 wt.% naphthalene 40 wt.% naphthalene

SEM

Oliveira, J.F., 2003

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‘Mecânica, Materiais Avançados e Nanotecnologia’

  • 3. HA-collagen composites

Sena, L.A., 2004

18 20 22 24 26 28 30 32 34 36 38 1000 2000 3000 4000 5000 6000 7000

Intensity (cps) 2θ

L002 = 17 nm L300 = 7 nm

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‘Mecânica, Materiais Avançados e Nanotecnologia’

  • 4. Zn-apatites calcinated at 1150°C

20 30 40 50

Znhap 20%

ZnTCP Hap

Znhap 10% Znhap 5% Hap

2θ

1200 1000 800 600 945 920 965 977 1009 1029 1065 1122 597 555 923 942 963 1029 1045 1020 1088 573 601 631 631 600 571 553 961 1045 1089 571 600 631 961 1045 1089

número de onda (cm

  • 1)

Hap calc. ZnHap 5% calc. ZnHap 10% calc. ZnHap 20% calc.

5%Zn - calc

5 10 15 20 25 30 10 20 30 40

[Zn] x 10

  • 5

Dias

Zn -ZnHap5c. Tris Zn -ZnHap5c. Hepes

Costa, A.M., 2004

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‘Mecânica, Materiais Avançados e Nanotecnologia’

SAMPLE COMPOSITION CDb 59.8 HA – 40.2 α-TCP Eb 95.4 HA – 4.6 α-TCP

  • 5. Cell culture on HA/α-TCP tablets

40 80 120 160 200 240 280 320

14D 7D 4D 2D 1D 4h

b

Cellular density (cells mm

  • 2)

Time in culture (days) CDb Eb

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‘Mecânica, Materiais Avançados e Nanotecnologia’

BONE FORMATION Depends on:

Surface Energy Surface Composition Topography

Materials for implants: Titanium and Ti-alloys

Jones, J., 2001

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‘Mecânica, Materiais Avançados e Nanotecnologia’

  • 1. Surface Treatment on cp Titanium
  • 538
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Ti-acid + oxide2 Ti-acid + oxide1 Ti-acid Ti

BINDING ENERGY (eV) INTENSITY

10 20 30 40 50 60 70 80 90 100

7 2 1

CALCIUM CONTENT INTO SBF (mg/L)

SOAKING TIME (days)

Ti-control Ti-etched Ti-etched + oxide 1 Ti-etched + oxide 2

Vanzillotta, P.S., 2003

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‘Mecânica, Materiais Avançados e Nanotecnologia’

2.Anodic oxidation with H3PO4

50V 100V 150V 200V Santos Jr., E., 2004

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‘Mecânica, Materiais Avançados e Nanotecnologia’

10 20 30 40 50 60 70 80 90

3 BEST THREADS ALL THREADS % CONTACT BONE-IMPLANT

c.p.Ti HA-coated Ti

  • 3. Ti Implants coated

with HA by Electrophoresis BSE image

Costa, C.A., 2002

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‘Mecânica, Materiais Avançados e Nanotecnologia’

Support

Collaboration

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‘Mecânica, Materiais Avançados e Nanotecnologia’

The future for biomaterials lies not in individual product areas, but in creating a marriage between materials science and biotechnology.

http://www.ecf.utoronto.ca/~bonehead/

Thank you!