I nstitut Pasteur: health research and Japan Science and Technology - - PDF document

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I nstitut Pasteur: health research and intervention w orld-w ide Paul Brey Japan Science and Technology Forum 5 October 2007

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I nstitut Pasteur ’s creation

1 8 8 7 : Established by international fund raising ( Russia, Brazil, Japan, France) follow ing L. Pasteur’s Rabies vaccine success « Our institute w ill be both a health center for treating rabies, a research center for infectious diseases and a learning center » Louis Pasteur

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I nstitut Pasteur and Japan : a long lasting relationship

• I n 1 8 8 6 , w hen Pasteur raised funds to

create the I nstitute, the personnel from a com pany from Yokoham a participated

• The first Japanese student in the

m icrobiology course w as Dr Yabe, in 1 8 9 7

• I n 1 9 2 2 , for centennial of Pasteur’s

birth, Japan donated 2 m agnificent

• vases. They now are in

the crypt, w here Pasteur is buried.

• I n 2 0 0 5 , the creation of the

Association Pasteur Japon

To help prom ote I nstitut Pasteur in Japan

Silk worm

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I nstitut Pasteur

The founding vision of I nstitut Pasteur is to im prove hum an health and w elfare through scientific discovery. Challenge Today: is to translate this vision into tw enty first century science and

technology within a complex global framework confronted with environmental change, emerging infectious disease and non-infectious diseases. Aim : is to is to continue to im prove hum an health and w elfare through scientific discovery by having a better understanding of the underlying mechanisms of environmental change on pathogens and their reservoirs as related to their mode of transmission, persistence and adaptation to

• humans. To integrate the most cutting edge technologies along with traditional natural history

studies on pathogens, as well as to better understand the mechanisms leading to cancer and neurological diseases.

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I nstitut Pasteur in 2 0 0 7

• Research

Study of infectious diseases, immune, genetic and neurological diseases for both prevention and cure.

• Public health

Reference Centers, WHO Collaborating Centers, Outpatient Medical center

• Education and training

1,100 students and trainees from 63 Countries

• International Network

30 Institutes on 5 continents

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I nstitut Pasteur in 2 0 0 7

A PRI VATE FOUNDATI ON

Annual budget (2006): 217 M €

Public Funding Donations & Legacies Business Development : fees, royalties, expert appraisals

35 % 32% 33 %

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Biom edical Research and Public Health

I nstitut Pasteur: Research

1 3 0 laboratories 2 0 cutting-edge core facilities

Genom ics and Proteom ics, Microarrays, Molecular Cryo-m icroscopy, TEM, Dynam ic I m aging, etc. I ncreasing efforts on neglected and em erging diseases. New labs and projects: Viruses ( Avian Flu, Chik, …) , Malaria, Leishm ania, Trypanosom a, Buruli ulcer

More than half of research is devoted to infectious diseases

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I nstitut Pasteur: biom edical research

Global Health and infectious diseases

Viral diseases AI DS, Flu, dengue, rabies, hepatitis, poliom yelitis, yellow fever, SARS, haem orrhagic fevers,... Bacterial diseases Tuberculosis, enteric diseases, plague, w hooping cough, m eningitis, anthrax, resistance to antibiotics,... Parasitic diseases Malaria, leishm aniasis, am ibiasis, Chagas disease, sleeping sickness... Fungal diseases Cryptococcosis, candidiasis, aspergillosis,...

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I nstitut Pasteur: biom edical research

Cancers, genetic diseases Neuroscience and Neurodegenerative disease: autism, deafness, Alzheimer’s Development of heart muscle Genomics and post- genomics etc...

I nstitut Pasteur

Vaccines Diagnostic tests Drugs Environment Incubator for start- up companies - several successful IPOs Technology transfer

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Public Health Services

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National Reference and W HO Collaborating Centers 20 Reference Centers and 8 WHO Collaborating Centers monitor epidemics; provide technical advice at the national and international level. For example : WHO reference center for Influenza and Rabies… CIBU : emergency intervention unit for unknown pathogens

• n call 24 hours, 7 days/week, 365 days/year

For example : SARS outbreak in China and Vietnam

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The Medical Center

a Center for international vaccination and travel m edicine an outpatient clinic, including tropical m edicine, derm atology, parasitology, m ycology and allergic reactions

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I nternational collaborations

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• To strengthen the scientific relations w ith

the other international organizations

• To develop projects in partnership w ith
• ther foundations or international actors:

W orld Health Organization ( W HO) GAVI ( Global Alliance for Vaccines and I m m unization) Bill & Melinda Gates Foundation DNDi ( Drugs for Neglected Diseases initiative) Bellagio Forum W ellcom e Trust - Oxford Tropical Medicine Unit U.S. Departm ent of Health and Hum an Services

• To prom ote the developm ent of regional

poles : Asia, Europe, Africa, Middle-East, Latin Am erica

The I nternational Collaborations

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Scientific collaborations Japan- I nstitut Pasteur in 2 0 0 7

1 . Collaborations w ith RI KEN

• Center for Developmental Biology, Kobe
• Research Center for Allergy & Immunology (RCAI),

Yokoham a

• RIKEN Tsukuba
• Research Institute for Microbial diseases (BIKEN),

Osaka

• Brain Science Institute (BSI), W ako

2 . Osaka University 3 . Tokyo University ( I MSUT)

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I nstitut Pasteur I nternational Netw ork

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Origin of the I nternational I nstitut Pasteur Netw ork

Three years after the establishment of Institut Pasteur in Paris, Louis Pasteur decided to establish Institut Pasteur

• utside of metropolitan France sending

his most talented young scientists to vaccinate populations against rabies and smallpox and to study infectious diseases “The future belongs to those who help suffering humanity” Louis Pasteur

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Le Réseau I nternational des I nstituts Pasteur

In 1891, Albert Calmette founded the first Institut Pasteur outside of metropolitan France in Saigon Today the network includes 30 institutes spanning five continents.

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The International network of Pasteur Institutes 30 Institutes Institut Pasteur Laos 2009

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I nstitut Pasteur I nternational Netw ork

• Public Health
• Research
• Teaching & Training
• Services
• Vaccine Production
• Technology transfer

Missions To improve research capacity To improve the public health in the countries where these institutes are located

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A few exam ples of activities and program s addressing global health challenges

• Avian flu diagnosis and surveillance ( Cam bodia, Laos,

Vietnam and China)

• Developm ent of rapid diagnosis “dip-sticks” for plague,

cholera, m eningitis ( I Ps in Africa)

• Distribution of bed nets and m alaria surveillance
• Rem ote Sensing Surveillance studies to help predict
• utbreaks of Vector borne and Avian borne diseases
• Food safety and Environm ental hygiene

Health and Sustainable developm ent

I nstitut Pasteur Netw ork in ASI A

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I nstituts Pasteur in Asia

• Korea
• Shanghai
• Hong-Kong
• Vietnam
• Cambodia
• Laos

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I nstitut Pasteur of Korea

Created in 2003 Staff : up to 250 people RESEARCH :

• Cancer, hepatitis, inflammation
• Therapeutics targets (malaria, AI)
• Enabling technology development

Synergies between:

• IP Paris: competence in Biological research & Therapy

development and

• IP Korea: competence in Information technology, Robotics,

Nanotechnology, Enabling Technology/ Research & Development

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I nstitut Pasteur de Shanghai / Chinese Academ y of Sciences

Created in 2004 Staff : up to 160 people RESEARCH :

• Virology : Emerging viral

diseases : SARS, bird flu, HIV/ AIDS, hepatitis

• encephalitis, hemorrhagic

fevers

• Immunology
• Epidemiology

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Hong-Kong University - Pasteur Research Centre

Created in 2000 Staff : 20 people RESEARCH :

• Emerging viral diseases:

SARS, bird flu

• Hepatitis C & HIV

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I nstituts Pasteur in Vietnam

IP Saigon 1891 (A. Calmette) IP Nha Trang 1895 (A. Yersin) IP Hanoi 1926 (N. Bernard) -> NIHE Staff : > 500 people Vietnamese Ministry

• f Health

RESEARCH :

• Prevention and treatment of infectious

diseases

• Emerging viral diseases: SARS, Avian

Influenza (H5N1), Encephalitis

• Bacterial diseases
• Dengue Fever/ Medical Entomology
• Hepatitis C HIV/ AIDS
• Vaccine production

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I nstitut Pasteur of Cam bodia

Created in 1927 Staff : 100 people RESEARCH :

• Prevention and treatment of infectious

diseases

• Emerging viral diseases: SARS, bird flu
• HIV/ AIDS
• Dengue
• Mycobacterium spp. Infections
• Malaria

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Institut Institut Pasteur Laos within Lao National Biomedical Campus Pasteur Laos within Lao National Biomedical Campus

IP Laos is a Lao National Research

Institute Research mandate on Emerging Viruses, Vector-Borne Disease and Environmental Impact on Human Disease Institut Pasteur Laos is funded by Institut Pasteur and the International Donor Community: European Commission, Luxembourg Government, French Government, Asian Development Bank.

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Installation of BSL3 facilities provides necessary bio-security to identify and investigate dangerous infectious agents

I nstitut Pasteur Netw ork in Asia

I nstallation of Level 3 Bio-security laboratories in I P Netw ork I nstitutes in Asia:

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A task force on severe acute respiratory A task force on severe acute respiratory infections and em erging viruses infections and em erging viruses Instituts Instituts Pasteur Paris, Cambodia, Korea, Pasteur Paris, Cambodia, Korea, Hong Kong, Shanghai, Vietnam, Laos, Hong Kong, Shanghai, Vietnam, Laos,

Objectives : Objectives :

1/ 1/ Novel diagnostics tools Novel diagnostics tools for Acute Respiratory

I nfections

2/ 2/ Surveillance Surveillance, , identification, characterization and

epidemiology of new ly em erging viruses in human populations

3/ New 3/ New antivira antiviral drugs l drugs 4/ New candidate 4/ New candidate vaccines vaccines 5/ Teaching and 5/ Teaching and training training

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R Research esearch-

• driven R

driven Resp esponse to

• nse to A

Acute cute R Respiratory espiratory I Infections nfections” ”, acronym RESPARI. , acronym RESPARI.

• This research program aim s to study

This research program aim s to study the follow ing aspects of acute the follow ing aspects of acute respiratory infections ( ARI ) of viral respiratory infections ( ARI ) of viral

• rigin ( H5 N1 , SARS etc.)
• rigin ( H5 N1 , SARS etc.)
• ( 1 ) standardized diagnosis and surveillance

in hum ans and anim als

• ( 2 ) epidem iology & natural history of

infectious agents ( Risk Factors, Reservoirs, Modes of Transm ission) .

• ( 3 ) the developm ent of new diagnostic

tools, based on biotechnologies ( pseudo- particles, quantum dots, m olecular beacons)

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I P Netw ork is reinforcing Avian I P Netw ork is reinforcing Avian I nfluenza research in the region I nfluenza research in the region

• Cam bodia, Laos, Vietnam and

China

• REI NFORCI NG DI AGNOSTI CS, SURVEI LLANCE

& RAPI D RESPONSE

Ability to detect and contain an outbreak at the source

• DATA COLLECTI ON / DATA MANAGEMENT /

H5 N1 SAMPLE SHARI NG/ DATA SHARI NG

Working closely with Regional Ministries of Health and WHO for Data Collection/ Data Management and Data and Sample sharing.

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I P Netw ork is reinforcing Avian I nfluenza research in the region

• Cam bodia, Laos, Vietnam and

China

• ENHANCI NG RESEARCH CAPACI TY

BUI LDI NG

We are actively participating in capacity building through-

• ut the region through training and participative research

projects not just sample collection.

• PUBLI C AW ARENESS

IP Network encourages media campaigns to improve public awareness

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Putative Putative Biotechnological Biotechnological Applications Applications may be may be derived from derived from IP Network RESPARI IP Network RESPARI program program

• National Institute of Hygiene and Epidemiology, (NIHE) Hanoi

National Institute of Hygiene and Epidemiology, (NIHE) Hanoi in collaboration with IMSUT Tokyo University in collaboration with IMSUT Tokyo University

• Institut Pasteur Ho Chi

Institut Pasteur Ho Chi Minh Minh City (IPHCMC) City (IPHCMC)

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AI H5N1 Vaccine Production

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Biotechnological Biotechnological Applications Applications derived from derived from IP IP Network RESPARI Network RESPARI program program

• Institut Pasteur Shanghai (IPS)

Institut Pasteur Shanghai (IPS)

• Centre

Centre Pasteur Pasteur at Hong at Hong Kong Kong University University (HKU (HKU-

• PRC

PRC) )

• Institut Pasteur

Institut Pasteur Korea Korea (IPK, (IPK, South Korea South Korea) )

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Avian Influenza A H5N1

• RAPID DIAGNOSTICS

RAPID DIAGNOSTICS

• DRUG SCREENING

DRUG SCREENING

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Teaching and Training w orldw ide

Teaching and training

Institut Pasteur has always been a pioneer in teaching new scientific disciplines

1889 : First course on Microbiology Today : 12 Master’s courses every year

800 students and interns from over 60 countries are trained each year in the Institute laboratories.

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Teaching and capacity building

Training and teaching of personnel within Institut Pasteur Network

Examples of courses in 2006-2007

• Pasteur-Asia Virology Course : HKU-Pasteur,Hong-Kong
• Malaria course : Institut Pasteur Madagascar
• Bio-Safety

and BSL3 level pathogenic agents: Institut Pasteur Shanghai

• Bioinform atics Institut Pasteur Dakar
• Rabies Diagnostics Institut Pasteur Ho Chi Minh City

I nstitut Pasteur : 2 0 0 8 -2 0 1 1

In 2008 : celebration of 120 years of Institut Pasteur In 2009 : Institut Pasteur Laos operational In 2010-2011 : project to create a new research center devoted to: « Integrative Biology of Emerging Diseases »

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