High-Throughput, Scalable Nanomanufacturing of Nanocomposites via - - PowerPoint PPT Presentation

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High-Throughput, Scalable Nanomanufacturing of Nanocomposites via - - PowerPoint PPT Presentation

Nov 02, 2023 174 likes •303 views

High-Throughput, Scalable Nanomanufacturing of Nanocomposites via Micellular Electrospray Jessica O. Winter William G. Lowrie Dept. of Chemical and Biomolecular Engineering, Department of Biomedical Engineering, The Ohio State University,

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SLIDE 1

High-Throughput, Scalable Nanomanufacturing of Nanocomposites via Micellular Electrospray

Jessica O. Winter

William G. Lowrie Dept. of Chemical and Biomolecular Engineering, Department of Biomedical Engineering, The Ohio State University, Columbus, OH

http://nano4neuro.com/

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SLIDE 2

Nanocomposite Particles

Quantum Dots Broad Excitation Narrow Emission Bandwidths Low photobleaching High Quantum Yield Magnetic Nanoparticles Reduce T2 relaxation (MRI) Biocompatible Biodegradable Exert force in magnetic field

Gu et al., JACS, 2004, 5664

Core-Shell

Deng et al., Nanotech., 2010, 145605.

Interfacial Doping

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SLIDE 3

Self-Assembled Micellar Nanocomposites

Ruan et al., Nano Letters, 2010, 2220; Ruan et al. J Nanoeng Nanosys, 2010, 81 Ruan, Winter, Nano Letters. 2011, 941.

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SLIDE 4

Interfacial Instability

Zhu JT, Hayward RC. Journal of the American Chemical Society. 2008;130:7496-502. Granek R, Ball RC, Cates ME. Journal De Physique Ii. 1993;3:829-49. Animation by A. Duong

1 batch ~ 0.1 mg

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SLIDE 5

Introduction to Electrospray

High Positive Voltage Applied Organic Solvent, Polymer, Nanoparticles Aqueous Solution: Water, Surfactant Ground Collection Dish (Water)

Collaboration with Barbara Wyslouzil, ChBE, OSU

Manuscript in Preparation

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SLIDE 6

Process Optimization

Q=3, Qo/Qi=14 Q=3.5, Qo/Qi=2.5

10 20 30 40 50 60 70 10 20 30 40 50 60

Collection Temperature ( C) PS-PEO Concentration in Organic (mg/ml)

Spheres Mix Worms & Spheres Not Viable Spheres Batch 2 Mix Worms & Spheres Batch 2

40 C 30 C 2 mg/ml 5 mg/ml 10 mg/ml

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SLIDE 7

Wormlike Micelles

Worms with QDs concentrated in globular regions Spherical micelles

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SLIDE 8

Yield and Size Distribution

30 fold increase in yield 15% size distribution

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SLIDE 9

Particles Produced and Uses

25 nm

MultiDot: QDs Imaging

50 nm

MagDot: Magnetic QDs Separations PolyDot: Polymer NPs Drug Delivery

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SLIDE 10

Conclusions

  • Micellar nanocomposites can be synthesized by

interfacial instability.

  • Nanocomposites can be synthesized by electrospray

increasing yield and with potential for continuous fabrication.

  • Synthesis is robust, with little change in

particles produced over a wide range of process parameters.

  • Alternative structures can be created by

altering polymer characteristics.

  • Several types of particles can be produced

using this approach.

  • Particles have applications in several fields.
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SLIDE 11

The Winter Group

Funding NSF Awards: CBET-0854015 , CMMI-0900377, CBET-0707969, MCB-1052623, EEC-0914790 (NSEC), DMR-0820414 (MRSEC), CMMI-1344567 NIH: 1RC2AG036559 – 01 DOE: Center for Integrated Nanotechnologies (CINT) The Ohio State University: Institute for Materials Research, Department of Chemical and Biomolecular Engineering, Women in Philanthropy, H.C. “Slip” Slider Professorship Collaborators: Jeff Chalmers (ChBE, OSU), Barbara Wyslouzil (ChBE, OSU), R. Sooryakumar (Physics, OSU), Maryam Lustberg (Med. Oncol., OSU), George Bachand (Sandia), Peter Kner (University of Georgia)

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SLIDE 12

Imaging Manipulation Biomimetics Drug Delivery

The Winter Lab at http://nano4neuro.com

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