Gloria Kolb Need for Retinal Implants Retinal Degeneration: Whats - - PowerPoint PPT Presentation

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Nov 29, 2023 136 likes •239 views

PROTEIN-BASED RETINAL IMPLANT ~ RESTORING VISION ~ Gloria Kolb Need for Retinal Implants Retinal Degeneration: Whats the Problem? The Implant Thin, tiny flexible implant Three main components Flexible, ion-permeable membrane

SLIDE 1

PROTEIN-BASED RETINAL IMPLANT ~ RESTORING VISION ~ Gloria Kolb

SLIDE 2

Need for Retinal Implants

SLIDE 3

Retinal Degeneration: What’s the Problem?

SLIDE 4

The Implant

Thin, tiny flexible implant
Three main components
Flexible, ion-permeable membrane
Positively charged polymer
Light activated protein – bacteriorhodopsin
One-time out-patient surgery

SLIDE 5

Advantages Over Competition

http://www.nytimes.com/2011/05/17/science/17optics.html?pagewanted=all&_r=0 http://accessscience.com/popup.aspx?id=YB110084&name=print http://www.bostonretinalimplant.org/

Gene therapy-

very early stage

f development
Electronic low-resolution

pixels

SLIDE 6

How we know it will work

Stimulated neural

circuitry of RP rat retinas

Activated using

ambient light

SLIDE 7

Expertise

Robert R. Birge, Founder
35+ years in vision research
Expert in bacteriorhodopsin-

based devices

CT Medal of Science

SLIDE 8

GMP production (ongoing)

Commercialization

3 US Patents
Manufacture, package, and sterilize implant
Biocompatibility
Surgical development and tool
Orphan Drug Indication (Combination Product)

Safety and efficacy in vivo work (2013-2014) IND application (2014-2015) Clinical trials (2015-2016) NDA (2016-2017)

SLIDE 9

Profitable

Reimbursement @ $60,000 90+% PROFIT!!
Looking for industry partners and venture capital