SLIDE 1
Georg August University, Göttingen, Germany
Wingender E. Compilation of transcription regulating proteins. Nucleic Acids Res. 1988 Mar 25;16(5):1879-902. PMID: 3282223
Gene Regulation 30 Years TRANSFAC Gttingen, March 07-09, 2018 - - PowerPoint PPT Presentation
Gene Regulation 30 Years TRANSFAC Gttingen, March 07-09, 2018 - - PowerPoint PPT Presentation
Bioinformatics of Gene Regulation 30 Years TRANSFAC Gttingen, March 07-09, 2018 Georg August University, Gttingen, Germany Wingender E. Compilation of transcription regulating proteins. Nucleic Acids Res. 1988 Mar 25;16(5):1879-902. PMID:
SLIDE 2
SLIDE 3
Transcription factor (TF) TF Binding Site Matrix
SLIDE 4
Wingender, E., Heinemeyer, T. and Lincoln, D., Regulatory DNA sequences: predictability of their function. Genome Analysis - From Sequence to Function; BioTechForum- Advances in Molecular Genetics (J. Collins, A.J. Driesel, eds.) 4, 95-108 (1991)
SLIDE 5
Wingender, E., Heinemeyer, T. and Lincoln, D., Regulatory DNA sequences: predictability of their function. Genome Analysis - From Sequence to Function; BioTechForum- Advances in Molecular Genetics (J. Collins, A.J. Driesel, eds.) 4, 95-108 (1991)
SLIDE 6
Sites Factors Factor classes Site models
TRANSFAC FACTOR TRANSFAC SITE TRANSFAC MATRIX TRANSFAC FRAGMENT TRANSFAC CLASS TFClass
Wingender, E., Kel, A., Krull, M., Transcription factor databases. Encyclopedia of Bioinformatics and Computational Biology (M. Cannataro et al., eds.), Chapter 20216 (2018)
SLIDE 7
SLIDE 8
Wingender, E., Heinemeyer, T. and Lincoln, D., Regulatory DNA sequences: predictability of their function. Genome Analysis - From Sequence to Function; BioTechForum- Advances in Molecular Genetics (J. Collins, A.J. Driesel, eds.) 4, 95-108 (1991)
SLIDE 9
The transcription core network
Gene 1 Gene 2 Gene 3
C B
Gene 1 Gene 2
gene expression trans-regulation
TF1
TF1 Gene 1 TF2 Gene 2 TF3 Gene 3
A
signaling signaling signaling
SLIDE 10
- C. E. Shannon, The Bell System Technical Journal, 27:379–423, 623–656 (1948)
SLIDE 11