esmo preceptorship on
play

ESMO PRECEPTORSHIP ON Gastric Cancer: Epidemiology (including GE - PowerPoint PPT Presentation

ESMO PRECEPTORSHIP ON Gastric Cancer: Epidemiology (including GE junction) and clinical presentation Dr Yong Wei Peng National University Cancer Institute, Singapore 20 Nov 2019 DISCLOSURES Advisory board: Abbie, Amgen, Aslan pharmaceutic,


  1. ESMO PRECEPTORSHIP ON Gastric Cancer: Epidemiology (including GE junction) and clinical presentation Dr Yong Wei Peng National University Cancer Institute, Singapore 20 Nov 2019

  2. DISCLOSURES Advisory board: Abbie, Amgen, Aslan pharmaceutic, BMS, Boston scientific, Ipsen, Novartis, Taiho Speaker bureau: BMS, Easai, Taiho Travel support: Eli Lilly

  3. INCIDENCES OF GC WORLDWIDE GLOBOCAN 2018 (IARC)

  4. GLOBOCAN 2018 (IARC)

  5. TRENDS IN INCIDENCES OF GC

  6. CAUSES FOR REDUCTION IN INCIDENCE AND MORTALITY Improved food preservation practices Early cancer detection • use of refrigeration • less pickling of vegetables • less smoking and processing of meat Surgical and oncologic advances • greater availability of fresh fruits and vegetables Reduction in H Pylori infection

  7. CARDIA CANCER

  8. RISK FACTORS FOR GC

  9. RISK FACTORS FOR GC

  10. H. Pylori infection

  11. PATHOGENESIS OF GASTRIC CANCER

  12. CAG - A IS A MAJOR VIRULENCE FACTOR OF H.PYLORI

  13. H.PYLORI IN WESTERN AND EAST ASIAN ISOLATES

  14. EBV INFECTION

  15. FAMILIAR GASTRIC CANCER SYNDROME

  16. FAMILIAR GASTRIC CANCER SYNDROME 10% of gastric cancers show familial clustering Hereditary Diffuse Gastric Cancer (E-cadherin mutation): Elevated risk of lobular breast cancer and possibly colorectal cancer. Histologically, gastric tumors are highly invasive, poorly differentiated, and display occasional signet ring cells. The lifetime penetrance of HDGC is about 65%, Age of onset shows from 14 years upward with a median age in the late thirties. ESMO Clinical Practice Guidelines: If a familial cancer syndrome such as hereditary diffuse GC (HDGC) is suspected, ideally, referral to a geneticist for assessment is recommended based on international clinical guidelines.

  17. LYNCH’S SYNDROME

  18. AETIOLOGY AND MOLECULAR CLASSIFICATION OF AGC AND EC

  19. CLINICAL PRESENTATION

  20. DIAGNOSIS & STAGING ESMO guideline recommendation: Diagnosis should be made from a gastroscopic or surgical biopsy reviewed by an experienced pathologist, and histology should be reported according to the World Health Organisation (WHO) criteria. https://oncologypro.esmo.org/Guidelines/Clinical-Practice-Guidelines/Gastrointestinal-Cancers/Gastric-Cancer

  21. CONCLUSIONS

  22. NATIONAL UNIVERSITY CANCER INSTITUTE, SINGAPORE

Recommend


More recommend