By practitioners, for practitioners By Claudia le Feuvre Dip BCNH - - PowerPoint PPT Presentation
An Introduction to CBD: By practitioners, for practitioners By Claudia le Feuvre Dip BCNH and Rory Batt MSc Personalised Nutrition www.mightygreen.co.uk June 2020 Agenda Who are Mighty Green? What is CBD? Is CBD Safe? What is
By Claudia le Feuvre Dip BCNH and Rory Batt MSc Personalised Nutrition www.mightygreen.co.uk June 2020
depression/ pain
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CBD (cannabidiol) is one of over 100 plant chemicals called cannabinoids that come from the plant genus Cannabis. CBD is one of the cannabinoids that is largely non-psychoactive. That means no nasty surprises when its used.
“CBD does not produce the effects that are typically seen with cannabinoids such as THC. It also failed to produce significant effects in a human study of abuse potential discussed
therapeutic effects of CBD it is generally well tolerated, with a good safety profile”
There are different types of CBD extract. CBD is CBD - there’s no changing that……. But, there’s more to an extract than just
compounds which are important. Some extracts contain other cannabinoids, in addition to compounds called Terpenes.
cbdoilusers.com
There are added benefits to having
1) Other cannabinoids have their own unique therapeutic effects. 2) They also have shared therapeutic effects with CBD. What this means……. 1) There is a greater diversity of therapeutic effects. 2) The effects of CBD are compounded by other cannabinoids.
This is where the compounds of hemp extracts work together in synergy. Together they produce a greater therapeutic effect than they would when given alone. In other words, the whole is greater than the sum
Were not just talking about cannabinoids, but Terpenes and Flavonoids as well.
Basically, the bodies own cannabinoid system. We make our own cannabinoids, known as Endocannabinoids. These communicate as chemical messengers via a network of special (cannabinoid) receptors. The ECS is a collective term for cannabinoid receptors, endocannabinoids and the metabolic enzymes which make and degrade them.
It was only discovered in the 1990’s Known as ‘the super computer that regulates homeostasis in all mammals’ for many functions including:
VanDolah, H. J., Bauer, B. A. and Mauck, K. F. (2019) ‘Clinicians’ Guide to Cannabidiol and Hemp Oils’, Mayo Clinic Proceedings. Elsevier Ltd, pp. 1840–
Nakagawa, Y. and Chiba, K. (2014) ‘Role of microglial M1/M2 polarization in relapse and remission of psychiatric disorders and diseases’, Pharmaceuticals. MDPI AG, pp. 1028–1048. doi: 10.3390/ph7121028.
Endocannabinoids regulate both the innate and adaptive immune systems (*). AEA is the most potent anti- inflammatory endocannabinoid, acting on most cell subsets (*). 2-AG exerts both pro- and anti- inflammatory effects - its effects are strictly dependent on cell type (*).
Pacher, P., Bátkai, S. and Kunos, G. (2006) ‘The endocannabinoid system as an emerging target of pharmacotherapy’, Pharmacological Reviews, pp. 389–462. doi: 10.1124/pr.58.3.2.
EC’s are synthesised from Omega- Fatty Acids. Since EC’s are also inflammatory regulators, their levels influence inflammatory tone. This is another way dietary n-6 influences levels of inflammation.
Bosch-Bouju, C. and Layé, S. (2016) ‘Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases’, in Cannabinoids in Health and Disease. InTech. doi: 10.5772/62498.
Balancing The ECS is the Key It can go either way: An underactive ECS has its issues. So does an overactive ECS Pharmacological manipulation is tricky, as the ECS is diverse and plays countless roles in human physiology. A great example is what happened with Rimonabant……..
Pacher, P. and Kunos, G. (2013) ‘Modulating the endocannabinoid system in human health and disease - successes and failures’, FEBS Journal. John Wiley & Sons, Ltd, 280(9), pp. 1918–1943. doi: 10.1111/febs.12260.
Lifestyle factors that influence how the ECS works:
Trauma ↓ CB1 receptors
↑ EC’s
CB2 Receptors ECS imbalance in disease:
The good news is, we can use CBD to help regulate the ECS. CBD can both enhance or reduce the activity of the ECS, to restore homeostasis based on individual requirements. How…..? By acting as an adaptogen: “A plant extract that is held to increase the body's ability to resist the damaging effects of stress and promote or restore normal physiological functioning”
Scharf, E. L. (2017) ‘Translating Endocannabinoid Biology into Clinical Practice: Cannabidiol for Stroke Prevention’, Cannabis and Cannabinoid Research. Mary Ann Liebert Inc., pp. 259–264.
Other plants besides cannabis (CBD) can also modulate the ECS, by enhancing levels of endocannabinoids and interacting directly with cannabinoid receptors.
Better sleep quality overall.
Short term - using CBD for greater duration may prove useful in staving off relapse.
Acute trial, but results encouraging
term follow up.
No studies looking directly at depression yet, but some secondary effects of CBD were found to influence depression. “Participants reported significantly fewer depressive and psychotic-like symptoms post treatment compared to baseline”
Solowij, N. et al. (2018) ‘Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial’, Cannabis and Cannabinoid Research. Mary Ann Liebert Inc., 3(1), pp. 21– 34.
Case report: Patient presented with pain, depression and anxiety. Following 3 months use of CBD; “She reported being less emotional and feeling calmer. She said that her anxiety dropped from 9/10 down to 3 to 4/10 and that her mood had stabilized”
Hegazy, O. and Platnick, H. (2019) ‘Cannabidiol (CBD) for Treatment of Neurofibromatosis-related Pain and Concomitant Mood Disorder: A Case Report’, Cureus. Cureus, Inc., 11(12).
Studies with CBD have also found it to be effective for managing pain. CBD (2.5mg per actuation) have been shown to significantly reduce neuropathic pain compared to placebo
That the ECS is involved in the pathophysiology of Metabolic Disease:
Oxidation)
Lipina, C. et al. (2012) ‘New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance’, BioEssays, pp. 681–691. doi: 10.1002/bies.201200031.
Western diet is high in Fructose and n-6, which drives increased production of EC’s. EC’s activate CB1 to promote energy storage, and discourage energy utilisation. Theoretically, CBD may help mitigate some pro-obesogenic/diabetic effects at the level of the CB1R, because it can block its activation. Although, this has yet to be proven clinically. Another cannabinoid THCV has been clinically proven to arrest Type 2 Diabetes progression.
Clark, T. M. et al. (2018) ‘ Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Cannabis Users ’, Cannabis and Cannabinoid Research. Mary Ann Liebert Inc, 3(1), pp. 259–271.
CBD packaging can seem confusing with various percentages and total mg's... The key is to know how many mg of CBD are in each drop so you can be very precise. Here's a summary of our 10ml oils which contain a total of 200 drops per bottle:
CBD is best consumed sub-lingually. Encourage clients to hold the oil there as long as they can.
We want to slowly activate the EndoCannabinoid System. Unsure what the ECS is? Read our blog. Some people may notice improvements immediately, others may take 10 days for the ECS to 'wake up'.
DAYS 1-5 5mg CBD in the morning 5mg CBD in the evening (especially if there are any sleep issues) Days 6-10 (increase the dose if not noticed an improvement in symptoms) 10mg CBD in the morning 10mg CBD in the evening After Day 10 The ECS should be activated. The client can continue with morning and evening dosages, or dose in response to symptoms (eg pain).
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