[PPT] - A Data Tracking Journey From Chronic Unknown Illness to Crystal PowerPoint Presentation

SLIDE 1

A Data Tracking Journey From Chronic “Unknown” Illness to Crystal Clear Diagnosis

Quan:fied Self Conference October 2013, San Francisco

SLIDE 2

Unknown Chronic Illness 2006 - 2007

Recovery Year – Bali, Indonesia & Chengdu, China

Exhaus6on Myalgia Exercise Intolerance

SLIDE 3

January 2012

Entrepreneur…. Gym Beast…. Overzealous Par:er…

Unknown Chronic Illness - June 2012

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Trembling Weak Muscles Numb Limbs/ Face Spark and Acute Headaches Altered Consciousness Nausea/ Vomi6ng Diarrhea Exhaus6on IntermiGent Fevers Neuropathy Loss of Neuromuscular Control Insomnia Emo6onal Extremes Stress Cons6pa6on Weight loss S6ff Neck Myalgia Dizzyness Short/ long term memory loss Brain Fog Lump on Head Stomach Ache Exercise Intolerance S6ff & Aching Joints

Lost in Complexity of Symptoms Brain Gut Nervous System General Flu-ness

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Conven:onal Data Collec:on

No Abnormali:es

– EEG (ElectroEncephaloGraphy) – MRI (Magne:c Resonance Imaging) – CT Scan (Computed Tomography)

Minor abnormali:es within ‘normal reference range’

– CBC (Complete Blood Count) – Liver Func:on – Lipids – hs-CRP

Approach #1: “Conven:onal Route”

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hs-CRP Inflamma:on Acute + Chronic Spikes

0.55 0.34 0.84 0.29 0.28 0.52 1.9 0.4 0.37 0.2 0.2 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2

hs-CRP (mg/L) Actual

Strange Acute Illness Chronic Illness Start Event

Approach #1: Conven:onal Route”

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LDL Infec:on Acute Spike

93 135 232 154 149 151 159 144 90.4 189 50 100 150 200 250

LDL (mg/dL) Op6mum Maximum Actual

Approach #1: “The Conven:onal Route”

Strange Acute Illness Chronic Illness Start Event

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Takeaways

Problems: No progress with Conven:onal

medicine

– Non-acute illness = Labs in “normal reference range” – Doesn’t fit “conven:onal templates” for illness

Progress: Baseline labs prior to sickness

– Showed ‘unhealthy change’ – Some kind of infec:on? (LDL, CRP spikes)

Approach #1: “Conven:onal Route”

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Data Collec:on

Labs

Heavy Metals (Doctor’s Data)
Vitamin D
Gene:cs (23andMe)
Micronutrient deficiencies

(Spectracell)

EFA (Essen:al Fajy Acids)
Iron/ Ferri:n Load
Homocysteine
Gut environment

(Metametrix)

Self Tracking

Symptoms
Blood sugar monitor
Sleep dura:on
Stool frequency/

consistency

Food intake
Supplement intake

Approach #2: “Track Everything”

Lumen Trails iPhone App www.lumentrails.com

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Quan:fying Symptoms + Factors = Confusing Mess

2 4 6 8 10 2000 4000 6000 8000 10000 3-Aug-12 2-Sep-12 2-Oct-12 1-Nov-12 1-Dec-12 Symptom Severity (1 - 10) Supplementa6on (Mcg/ Mg) M-B12 - Jarrows (Mcg) M-B12-Enzyma:c Therapies M-B12-NOW A-B12-Country Life Folic Acid Folinic Acid Jarrow Methyl Folate (Quatrefolic) Solgar Folate (Metafolin) Mcg Upgraded Glutathione (Mg) Lipoceu:cal Glutathione (Mg) NAC (Mg) Symptoms

Approach #2: “Track Everything”

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Journal Factors + Quan:fy 1 Symptom = Insight

Approach #2: “Track Everything”

2 4 6 8 10

12/15/12 12/18/12 12/21/12 12/24/12 12/27/12 12/30/12 1/2/13 1/5/13

Energy Levels

Coffee or Chocolate = Energy Crash

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Elimina:on Experiment to Prove

Approach #2: “Track Everything”

Hypotheses Experiment

Pet name given to illness project

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Takeaways

Progress: ‘Specific’ avoidance helps manage

symptoms

– Gluten, Casein = Gut Issues – Chocolate and Coffee = Energy crashes – Are these clues?

Problems:

– No closer to a ‘diagnosed illness’ progress – How can I work smarter?

Approach #2: “Track Everything”

SLIDE 14

Nervous System and “Trembling”

Trembling Weak Muscles Numb Limbs/ Face Spark and Acute Headaches Altered Consciousness Nausea/ Vomi6ng Diarrhea Exhaus6on IntermiGent Fevers Neuropathy Loss of Neuromuscular Control Insomnia Emo6onal Extremes Stress Cons6pa6on Weight loss S6ff Neck Myalgia Dizzyness Exercise Intolerance Short/ long term memory loss Brain Fog Lump on Head S6ff & Aching Joints

Approach #3: Find “Uniqueness”

SLIDE 15

Data Collected

Lab Test

– Epstein Barr Virus an:bodies (raised)

Experiment

– 1 week on psychoac:ve drug Deanxit to link to sympathe:c nervous system ac:va:on – (Stopped the trembling)

Approach #3: Find “Uniqueness”

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Takeaways

Progress:

– Got a diagnosis “Chronic Fa:gue Syndrome (CFS)”

Problems:

– CFS is not a differen:al diagnosis. Groups people loosely with similar symptoms and very rough biomarkers. – CFS is an incurable and progressive illness.

Approach #3: Find “Uniqueness”

SLIDE 17

Aser Lots of Reading…

Metabolic Rate Increase Free Radical Burden Increase Thiol + Enzyme An:oxidant Deple:on Thiol + Enzyme An:oxidant System Overwhelmed Methyla:on Gene Defects Pathogens (virus, bacteria, parasite, fungi/ molds) Mitochondrial Damage Immune System Ac:va:on Radia:on (X-Rays, Sun) Free Radical Consump:on (Oxidized Food) Stress / Lack of Sleep Internal Free Radical Produc:on Increase Metabolic Ac:vity (Exercise) Repair & Regenerate Mitochondria An:oxidant Support Toxins (Mycotoxins, Biotoxins, Metals, Chemicals) Support & Bypass Defects Targeted An:- Pathogenics (an:bio:cs, an:virals, immune system modulators, an:microbials) Chela:on / Toxin Removal Limit Exposure

LEGEND

Diseased Process in Body Recovery Interven:ons Root Cause Inputs to Disease Nega:ve Feedback Interference Limit Exposure Detox Supports

Vicious Declining Circle

Approach #4: “Ajack Everything!”

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Data Collec:on

Blood Labs

– Methyla:on profile and gene:cs (low methyla:on/ glutathione, high

xida:on, low detox func:on)

– Mitochondrial profile (low mitochondrial func:on, high DNA damage)

Urine Labs - substrates

– Urine Amino Acids (high ammonia) – Essen:al Elements (low potassium)

Pathogens/ Toxic burden

– Stool test (Blastocyst hominis, helicobacter pylori posi:ve) – Heavy metals urine and hair tests (high arsenic, mercury, uranium, cesium)

Biometrics via Tracking Devices

– MyBasis watch - perspira:on, heart rate, sleep (night sweats, short sleep dura:on) – HRV monitors - emwave2, chest strap + HRV sense (low HRV, high stress, sympathe:c ac:va:on, heart rate jump on exer:on)

Approach #4: “Ajack Everything!”

SLIDE 19

Homocysteine

9.23 9.68 7.1 6.6 7.5 2 4 6 8 10 12

Homocysteine (µmol/L) Op6mum Maximum Actual

Approach #4: “Ajack Everything!”

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Takeaways

Progress

– Lots of “out of normal reference range” data – Clear methyla:on and mitochondria damage – Managing condi:on now – not gevng worse. – Silverlining: Discovered many other health issues

Approach #4: “Ajack Everything!”

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Takeaways

Problems

– High investment, low return: Lots of :me and effort to make lijle progress. – No Clear Cause: No clear cut hypotheses for cause

f illness supported by data.

– Not likely to cure: Some people go into remission through symptoms management, but not cured.

Approach #4: “Ajack Everything!”

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Who aggregates and analyzes lots of data?

Methyla6on and CFS >> Dr. Amy Yasko

– All pa:ents repor:ng back data monthly – Wide variety of tests – Analyzes aggregate data by gene:c fingerprint – Adjusts hypotheses and protocols on ongoing basis

Approach #5: Find “Big Data”

SLIDE 23

Cri:cal Mass of Insights: The “Mold” Connec:on

Dave Asprey’s blog

– Coffee + chocolate osen contain “Mycotoxins” – Mycotoxins are toxin secreted by Mold

Unique symptoms

– Coffee + Chocolate = Energy crash

Flashback: I stayed in a house with visible

mold in 2011

Approach #5: Find “Big Data”

SLIDE 24

Who aggregates and analyzes lots of data?

“Mold” and Biotoxin Illnesses

– Dr. Ritchie Shoemaker – 16 years of data and published studies – Clear recovery protocol for “Cure”

Approach #5: Find “Big Data”

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Data Collec:on

Dr. Ritchie Shoemaker – “Biotoxin Illness”

– Screening: Visual Contrast Sensi:vity, Symptoms Clusters – Specific Gene6cs: HLA - Human Leukocyte An:gens (Mold suscep:ble, post-lyme suscep:ble) – Specialized labs: Innate immune system inflamma:on markers (C4a, C3a, TGF-Beta 1) and many other markers of differen:al damage

Approach #5: Find “Big Data”

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Takeaways

“Winning!”– Clear diagnosis for Biotoxin Illness

– Symptoms cluster posi6ve: sta:s:cal significance – Visual Contrast Sensi:vity posi6ve: > 50% below controls – Gene:c fingerprints posi6ve: Both biotoxin and methyla:on defect suscep:ble – Lab fingerprints posi6ve: Specific inflamma:on present

Approach #5: Find “Big Data”

SLIDE 27

Find “Big Data” AGack Everything Find “Unique” Track Everything Conven6onal Route

Each Approach Pushed the Journey On…

Conclusion

1 2 3 4 5

Progress

Cri:cal Mass of Insights Eliminated Typical Illnesses Cancers, MS, Parkinsons, Viral meningi<s etc. Weird Insight Coffee + chocolate = Energy Crash Narrowed Research Area to Chronic Fa<gue Syndrome Iden6fied Many Biomarkers to Fix Methyla<on, Mitochondria etc. Clear Cut Diagnosis

SLIDE 28

VCS - Progress w/ Treatment Since Diagnosis Conclusion

48 62 72 80 83 10 20 30 40 50 60 70 80 90 100 14-Apr-13 21-Apr-13 28-Apr-13 5-May-13 12-May-13 19-May-13 26-May-13 2-Jun-13 9-Jun-13 16-Jun-13 23-Jun-13 30-Jun-13 7-Jul-13 14-Jul-13 21-Jul-13 28-Jul-13 4-Aug-13 11-Aug-13 18-Aug-13 25-Aug-13 1-Sep-13 8-Sep-13 15-Sep-13 22-Sep-13

Visual Contrast Sensi6vity (VCS) Score Biotoxin +ve Cutoff VCS

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How Much Did this Cost So Far?

Conclusion

$0 $5,000 $10,000 $15,000 $20,000 $25,000 Mar-12 Apr-12 May-12 Jun-12 Jul-12 Aug-12 Sep-12 Oct-12 Nov-12 Dec-12 Jan-13 Feb-13 Mar-13 Apr-13 May-13 Jun-13 Jul-13 Aug-13 Sep-13 Oct-13

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